Ethyl 2-amino-5-hydroxy-4-methylsulfanyl-furo[2,3-f]quinazoline-3-carboxylate | 1355613-27-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: Ethyl 2-amino-5-hydroxy-4-methylsulfanyl-furo[2,3-f]quinazoline-3-carboxylate
• 英文别名: ethyl 2-amino-5-hydroxy-4-methylsulfanylfuro[2,3-f]quinazoline-3-carboxylate
• CAS: 1355613-27-2
• 化学式: C₁₄H₁₃N₃O₄S
• 分子量: 319.341
• InChiKey: LGEUPMUDQVANSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  137
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  6,7-二氯喹唑啉-5,8-二酮 在 ammonium hydroxide 、 cerium(III) chloride 作用下， 以 乙醇 为溶剂， 反应 5.17h， 生成 Ethyl 2-amino-5-hydroxy-4-methylsulfanyl-furo[2,3-f]quinazoline-3-carboxylate
  参考文献：
  名称：

  Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols

  摘要：

  6,7-Bis(arylthio)-quinazoline-5,8-dione and furo[2,3-f]quinazolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many of furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones showed good antifungal activity. The compounds 4a and 4e completely inhibited the growth of all against Candida and Aspergillus species tested at the MIC level of 12.5 mu g/mL. The results suggest that furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones would be promising antifungal agents. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.10.099

文献信息

• Synthesis and antifungal activity of 6,7-bis(arylthio)-quinazoline-5,8-diones and furo[2,3-f]quinazolin-5-ols
  作者：Chung-Kyu Ryu、Yang Hui Kim、Hyun Ah Im、Ji Young Kim、Joo Hee Yoon、Aram Kim

  DOI：10.1016/j.bmcl.2011.10.099

  日期：2012.1

  6,7-Bis(arylthio)-quinazoline-5,8-dione and furo[2,3-f]quinazolin-5-ol derivatives were synthesized and tested for in vitro antifungal activity against Candida, Aspergillus species, and Cryptococcus neoformans. Among them tested, many of furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones showed good antifungal activity. The compounds 4a and 4e completely inhibited the growth of all against Candida and Aspergillus species tested at the MIC level of 12.5 mu g/mL. The results suggest that furo[2,3-f]quinazolin-5-ols and 6,7-bis(arylthio)-quinazoline-5,8-diones would be promising antifungal agents. (C) 2011 Elsevier Ltd. All rights reserved.