Bromodeoxyuridine (brdu)

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Bromodeoxyuridine (brdu)
• 英文别名: 5-bromo-1-[(2R,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
• 化学式: C₉H₁₁BrN₂O₅
• 分子量: 307.1
• InChiKey: WOVKYSAHUYNSMH-JXBXZBNISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  99.1
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Drug delivery from rapid gelling polymer composition
  申请人：ANGIOTECH INTERNATIONAL AG

  公开号：EP2181704A2

  公开（公告）日：2010-05-05

  Compositions are disclosed that afford drug delivery from two-part polymer compositions that rapidly form covalent linkages when mixed together. Such compositions are particularly well suited for use in a variety of tissue related applications when rapid adhesion to the tissue and gel formation is desired along with drug delivery. For example, the compositions are useful as tissue sealants, in promoting hemostasis, in effecting tissue adhesion, in providing tissue augmentation, and in prevention of surgical adhesions.

  本发明公开了一些组合物，这些组合物由两部分聚合物组成，在混合在一起时可迅速形成共价连接，从而实现药物输送。当需要快速粘附组织和形成凝胶并同时给药时，这种组合物特别适合用于各种与组织相关的应用。例如，这种组合物可用作组织密封剂、促进止血、实现组织粘合、提供组织增量以及防止手术粘连。
• NUCLEIC ACID BINDING COMPOUNDS CONTAINING PYRAZOLO¬3,4-D PYRIMIDINE ANALOGUES OF PURIN-2,6-DIAMINE AND THEIR USES
  申请人：Roche Diagnostics GmbH

  公开号：EP1307469B1

  公开（公告）日：2008-01-23
• DRUG DELIVERY FROM RAPID GELLING POLYMER COMPOSITION
  申请人：ANGIOTECH INTERNATIONAL AG

  公开号：EP1594459B1

  公开（公告）日：2010-02-17
• COMPOSITIONS AND METHODS FOR TREATING CONTRACTURE
  申请人：ANGIOTECH INTERNATIONAL AG

  公开号：EP1708694B1

  公开（公告）日：2012-07-11