9H-fluoren-9-ylmethyl N-[(2,4-dimethoxyphenyl)-(4-ethoxyphenyl)methyl]carbamate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl N-[(2,4-dimethoxyphenyl)-(4-ethoxyphenyl)methyl]carbamate
• 化学式: C₃₂H₃₁NO₅
• 分子量: 509.6
• InChiKey: VJILQCVQVARWSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  38
• 可旋转键数：
  10
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  9H-fluoren-9-ylmethyl N-[(2,4-dimethoxyphenyl)-(4-ethoxyphenyl)methyl]carbamate 生成 (2,4-Dimethoxyphenyl)-(4-ethoxyphenyl)methanamine
  参考文献：
  名称：

  J. Org. Chem. 2001, 66, 5859-5865

  摘要：

  DOI：

文献信息

• ANTIVIRAL COMPOSITIONS
  申请人：VERRECK Geert

  公开号：US20100172970A1

  公开（公告）日：2010-07-08

  The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.

  本发明涉及抗病毒化合物的制药组合物，可用于治疗哺乳动物，特别是人类的病毒感染。这些组合物包括通过熔融挤出一种或多种抗病毒化合物和一种或多种适当的水溶性聚合物的混合物获得的颗粒，并随后研磨该熔融挤出的混合物。
• Novel peptides that bind to the erythropoietin receptor
  申请人：Holmes P. Christopher

  公开号：US20070027074A1

  公开（公告）日：2007-02-01

  The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention also relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
• METHODS FOR PREPARING INTERNALLY CONSTRAINED PEPTIDES AND PEPTIDOMIMETICS
  申请人：Arora Paramjit

  公开号：US20070197772A1

  公开（公告）日：2007-08-23

  The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.
• Compositions and Methods for Inhibiting Cellular Proliferation
  申请人：Hembrough Todd

  公开号：US20080090760A2

  公开（公告）日：2008-04-17

  Compositions and methods effective in inhibiting abnormal or undesirable cell proliferation, particularly endothelial cell proliferation and angiogenesis related to neovascularization and tumor growth are provided. The compositions comprise peptide molecules, optionally containing one or more individual peptide chains covalently linked, and optionally modified with polyethylene glycol (PEG). The methods involve administering to a human or animal the composition described herein in a dosage sufficient to inhibit cell proliferation, particularly endothelial cell proliferation. The methods are useful for treating diseases and processes mediated by undesired and uncontrolled cell proliferation, such as cancer, particularly by inhibiting angiogenesis. Administration of the composition to a human or animal having prevascularized, metastasized tumors is useful for preventing the growth or expansion of such tumors.
• Methods for Preparing Internally Constrained Peptides and Peptidomimetics
  申请人：Arora Paramjit

  公开号：US20100234563A1

  公开（公告）日：2010-09-16

  The present invention relates to a method for preparing a peptide having a stable, internally constrained alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region and a method of stabilizing an alpha-helical, beta-sheet/beta-turn, 3 10 -helical, or pi-helical region within a peptide structure. The resulting peptides and methods of using them are also disclosed.