Rink Amide AM resin (100-200 mesh)

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: Rink Amide AM resin (100-200 mesh)
• 英文别名: 9H-fluoren-9-ylmethyl N-[(2,4-dimethoxyphenyl)-[4-[2-[(4-methylphenyl)methylamino]-2-oxoethoxy]phenyl]methyl]carbamate
• 化学式: C₄₀H₃₈N₂O₆
• 分子量: 642.7
• InChiKey: NZMJHARNPOGNCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  48
• 可旋转键数：
  13
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• DERIVATIVES, REAGENTS, AND IMMUNOASSAY FOR DETECTING LEVETIRACETAM
  申请人：Ouyang Anlong

  公开号：US20100317024A1

  公开（公告）日：2010-12-16

  Levetiracetam (LEV) derivatives, methods for synthesizing LEV derivatives, and immunodiagnostic assays for LEV. The synthesis methods described herein include chirally-selective, liquid-phase synthesis steps to produce selected LEV derivatives in high-yield. LEV derivatives can include operative groups, such as: immunogenic moieties that can be used to prepare anti-LEV antibodies; antigenic moieties that can be used in immunodiagnostic assays for LEV; or tracer moieties that can be used in immunodiagnostic assays. Additionally, the LEV derivatives can be used in immunodiagnostic assays to compete with LEV for anti-LEV antibodies.

  Levetiracetam (LEV)衍生物，合成LEB衍生物的方法，以及用于LEV的免疫诊断试验。本文所描述的合成方法包括手性选择性、液相合成步骤，以高产率生产选定的LEV衍生物。LEV衍生物可以包括操作基团，例如：可用于制备抗LEV抗体的免疫原性基团；可用于LEV的免疫诊断试验中的抗原性基团；或可用于免疫诊断试验中的示踪基团。此外，LEV衍生物可以用于免疫诊断试验，以与抗LEV抗体竞争LEV。
• EPTIFIBATIDE PREPARATION METHOD
  申请人：WEN Yongjun

  公开号：US20150299261A1

  公开（公告）日：2015-10-22

  An Eptifibatide preparation method with product purity of more than 99.5%, the method comprising: using a solid phase polypeptide synthesis method to prepare eptifibatide resin, conducting acidolysis on the Eptifibatide resin to obtain a crude Eptifibatide linear peptide product, oxidizing to obtain a crude Eptifibatide product, purifying and exchanging salt to obtain an Eptifibatide finished product; the method using the solid phase polypeptide synthesis method to prepare the eptifibatide resin is: using a solid phase coupling synthesis method to sequentially splice a corresponding protective amino acid or a segment in the following sequence onto amino resin, and obtaining the Eptifibatide resin: X—Y-Trp(R 1 )-Pro-Cys(R 2 )-amino resin, wherein R 1 is Boc or H, R 2 is Trt or Acm, X is Mpr(R 2 )-Harg(R 3 ), R 3 is Pbf or H, and Y is Gly-Asp(OtBu).
• MACROCYCLIC BROAD SPECTRUM ANTIBIOTICS
  申请人：RQX PHARMACEUTICALS, INC.

  公开号：US20170088582A1

  公开（公告）日：2017-03-30

  Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.
• US8846411B2
  申请人：——

  公开号：US8846411B2

  公开（公告）日：2014-09-30
• US9394341B2
  申请人：——

  公开号：US9394341B2

  公开（公告）日：2016-07-19