GlcA(?1-5)Ribf(b)-uracil-1-yl

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: GlcA(?1-5)Ribf(b)-uracil-1-yl
• 英文别名: (2S,3S,4S,5R)-6-[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid
• 化学式: C₁₅H₂₀N₂O₁₂
• 分子量: 420.33
• InChiKey: XIHBPXSWFMCKFM-MCYVOLKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  216
• 氢给体数：
  7
• 氢受体数：
  12

文献信息

• MICROSOMAL BIOREACTOR FOR SYNTHESIS OF DRUG METABOLITES
  申请人：THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY

  公开号：US20180044657A1

  公开（公告）日：2018-02-15

  Reusable microsomal biocatalytic systems (bioreactors) constructed on carbon nanostructure modified electrodes are provided. The bioreactors comprise stable, biologically active immobilized enzymes such as human cytochromes P 450 (CYPs) and their redox partner proteins, e.g. CYP-NADPH (reduced nicotinamide adenine dinucleotide phosphate) reductases (CPR), on the carbon nanostructure surface. The immobilized enzymes may be present in liver microsomes, such as human liver microsomes (HLM) or as bactosomes, S9 fractions, etc. The bioreactors are used, for example, for synthesizing metabolites of interest from compounds such as drugs that are catabolized by the enzymes.
• [EN] MICROSOMAL BIOREACTOR FOR SYNTHESIS OF DRUG METABOLITES<br/>[FR] BIORÉACTEUR DE MICROSOMES POUR LA SYNTHÈSE DE MÉTABOLITES DE MÉDICAMENT
  申请人：UNIV OKLAHOMA STATE

  公开号：WO2016138477A1

  公开（公告）日：2016-09-01

  Reusable microsomal biocatalytic systems (bioreactors) constructed on carbon nanostructure modified electrodes are provided. The bioreactors comprise stable, biologically active immobilized enzymes such as human cytochromes P 450 (CYPs) and their redox partner proteins, e.g. CYP-NADPH (reduced nicotinamide adenine dinucleotide phosphate) reductases (CPR), on the carbon nanostructure surface. The immobilized enzymes may be present in liver microsomes, such as human liver microsomes (HLM) or as bactosomes, S9 fractions, etc. The bioreactors are used, for example, for synthesizing metabolites of interest from compounds such as drugs that are catabolized by the enzymes.