4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydron;hydrochloride

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 4-amino-1-[(2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydron;hydrochloride
• 化学式: C9H13ClF2N3O4+
• 分子量: 300.67
• InChiKey: OKKDEIYWILRZIA-OSZBKLCCSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -1.45
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  108
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• MATERIALS AND METHOD FOR TREATING INTERNAL BODY CAVITIES
  申请人：UroGen Pharma Ltd.

  公开号：EP2734187B1

  公开（公告）日：2018-09-05
• [EN] MATERIALS AND METHOD FOR TREATING INTERNAL BODY CAVITIES<br/>[FR] MATÉRIAUX ET MÉTHODE DE TRAITEMENT DE CAVITÉS CORPORELLES INTERNES
  申请人：THERACOAT LTD

  公开号：WO2013011504A1

  公开（公告）日：2013-01-24

  The use of a thermoreversible hydrogel in a system for delivering a therapeutic agent to tissue is disclosed. The thermoreversible hydrogel is characterized by a viscosity of less than 200 Pa s over a temperature range of 4 °C - 12 °C; a viscosity of greater than 103 Pa.s at 37 °C; a "peel strength" adhesiveness according to ASTM standard D2256-03 of 0.5 - 5.0 N cm"2 at 37 °C; and flexibility sufficient such that a 3 cm2 χ 3 cm2 section of bladder tissue layered with said thermoreversible hydrogel at room temperature can be stretched to 9 cm2 x 9 cm2 without detachment of said thermoreversible hydrogel from said bladder tissue.