9H-fluoren-9-ylmethyl 2H-benzotriazole-4-carboxylate

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 9H-fluoren-9-ylmethyl 2H-benzotriazole-4-carboxylate
• 化学式: C₂₁H₁₅N₃O₂
• 分子量: 341.4
• InChiKey: OWOSDWFRNBYFGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  67.9
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Thioamide-modified peptides and uses thereof
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10189884B2

  公开（公告）日：2019-01-29

  The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.

  本发明包括硫代酰胺修饰的多肽，其中硫代酰胺修饰增加了多肽的体内半衰期。本发明还包括治疗或预防有需要的受试者的疾病或失调的方法，该方法包括给受试者施用本发明的硫代酰胺修饰的多肽。
• Method of stabilizing a bioactive peptide against protease hydrolysis
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US10947290B2

  公开（公告）日：2021-03-16

  The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.

  本发明包括硫代酰胺修饰的多肽，其中硫代酰胺修饰增加了多肽的体内半衰期。 本发明还包括治疗或预防有需要的受试者的疾病或失调的方法，该方法包括给受试者施用本发明的硫代酰胺修饰的多肽。
• NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20170044231A1

  公开（公告）日：2017-02-16

  The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
• THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF
  申请人：THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

  公开号：US20210198338A1

  公开（公告）日：2021-07-01

  The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.
• [EN] NOVEL THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF<br/>[FR] NOUVEAUX PEPTIDES À MODIFICATION THIOAMIDE ET LEURS UTILISATIONS
  申请人：UNIV PENNSYLVANIA

  公开号：WO2015168135A1

  公开（公告）日：2015-11-05

  The invention includes a thioamide-modified peptide, wherein the thioamide modification increases the in vivo half-life of the peptide. The invention further includes methods of treating or preventing a disease or disorder in a subject in need thereof, the method comprising administering to the subject a thioamide-modified peptide of the invention.