[5-(2,4-Dioxopyrimidin-1-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-yl] 4-oxopentanoate

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: [5-(2,4-Dioxopyrimidin-1-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-yl] 4-oxopentanoate
• 英文别名: [5-(2,4-dioxopyrimidin-1-yl)-4-fluoro-2-(hydroxymethyl)-4-methyloxolan-3-yl] 4-oxopentanoate
• 化学式: C₁₅H₁₉FN₂O₇
• 分子量: 358.32
• InChiKey: SWKKZUNPXPFJFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] NOVEL NUCLEOTIDE ANALOGS, PROCESS FOR THE PREPARATION OF SOFOSBUVIR AND ITS ANALOGS, NOVEL FORMS OF SOFOSBUVIR AND SOLID DISPERSION OF SOFOSBUVIR<br/>[FR] NOUVEAUX ANALOGUES DE NUCLÉOTIDES, PROCÉDÉ DE PRÉPARATION DE SOFOSBUVIR ET DE SES ANALOGUES, NOUVELLES FORMES DE SOFOSBUVIR DE DISPERSION SOLIDE DE SOFOSBUVIR
  申请人：REDDY’S LAB LTD DR

  公开号：WO2016035006A1

  公开（公告）日：2016-03-10

  Aspects of the present application relate to novel nucleotide analogs, their use in the preparation of nucleoside phosphoramidates, (2R)-2-deoxy-2-fluoro-2-C- methyl-D-ribofuranose compounds, their use in the preparation of nucleoside phosphoramidates, stereoselective preparation of sofosbuvir, crystalline polymorph, cocrystal of sofosbuvir, processes for their preparation, amorphous solid dispersion of sofosbuvir and processes for the preparation of amorphous sofosbuvir.