2-(benzo[d]thiazol-2-yl)-N'-hydroxyacetimidamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻唑类
• 英文名称: 2-(benzo[d]thiazol-2-yl)-N'-hydroxyacetimidamide
• 英文别名: 2-(1,3-benzothiazol-2-yl)-N'-hydroxyethanimidamide
• 化学式: C₉H₉N₃OS
• mdl: MFCD04110178
• 分子量: 207.256
• InChiKey: YKIOTVXPLPMYSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  99.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(benzo[d]thiazol-2-yl)-N'-hydroxyacetimidamide 、 对氯苯甲酸 在 N,N'-羰基二咪唑 作用下， 以 乙腈 为溶剂， 以93 %的产率得到N'-[(4-chlorobenzoyl)oxy]-1,3-benzothiazole-2-carboximidamide
  参考文献：
  名称：

  N'-[(4-chlorobenzoyl)oxy]-1,3-benzothiazole-2-carboximidamide as an antitumor and antimicrobial compound

  摘要：

  A N′-[(4-chlorobenzoyl)oxy]-1,3-benzothiazole-2-carboximidamide compound, its synthesis, and its use as an anticancer and/or antimicrobial agent.

  公开号：

  US11912676B1

文献信息

• Substituted Acyloxyamidines as HCV NS3/4A Inhibitors
  申请人：ViroCura Therapeutics, Inc.

  公开号：US20150133495A1

  公开（公告）日：2015-05-14

  Disclosed herein is a compound of Formula I or a pharmaceutically acceptable salt thereof, in which A, G, R 1 and R 2 are as defined herein. The compounds and pharmaceutical compositions of the compounds are suitable for the treatment of HCV infection in mammals and are also useful to modulate or inhibit NS3/4 dimerization.

  本文公开了一种I式化合物或其药学上可接受的盐，其中A、G、R1和R2的定义如本文所述。这些化合物及其制剂适用于哺乳动物HCV感染的治疗，并且也有用于调节或抑制NS3/4二聚体化的作用。
• 2-(benzo[d]thiazol-2-yl)-N'-(2-(5-phenyl-1,3,4-oxadiazol-2-ylthio)acetoxy)acetimidamide as an antimicrobial compound
  申请人：KING FAISAL UNIVERSITY

  公开号：US11970488B1

  公开（公告）日：2024-04-30

  A 2-(benzo[d]thiazol-2-yl)-N′-(2-(5-phenyl-1,3,4-oxadiazol-2-ylthio)acetoxy)acetimidamide compound, its synthesis, and its use as an antimicrobial agent.
• 1,3-benzothiazol-2-yl-N′-(benzoyloxy)ethanimidamide as an antitumor and antimicrobial compound
  申请人：KING FAISAL UNIVERSITY

  公开号：US11919873B1

  公开（公告）日：2024-03-05

  A compound 1,3-benzothiazol-2-yl-N′-(benzoyloxy)ethanimidamide, its synthesis, and its use as an anticancer and/or antimicrobial agent.
• 2-(benzo[d]thiazol-2-yl)-N'-(2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio)acetoxy)acetimidamide as an antimicrobial compound
  申请人：KING FAISAL UNIVERSITY

  公开号：US11919892B1

  公开（公告）日：2024-03-05

  A 2-(benzo[d]thiazol-2-yl)-N′-(2-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-ylthio) acetoxy)acetimidamide compound, its synthesis, and its use as an antimicrobial agent.