1-(4-but-3-enoxyphenyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: 1-(4-but-3-enoxyphenyl)-6-chloro-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole
• 化学式: C₂₁H₂₁ClN₂O
• 分子量: 352.9
• InChiKey: WTYSCWDSPGSVRU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  37
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS
  申请人：PTC Therapeutics, Inc.

  公开号：EP2434891B9

  公开（公告）日：2021-05-05
• METHOD OF INHIBITING OR REDUCING A CORONAVIRIDAE VIRUS INFECTION
  申请人：PTC Therapeutics, Inc.

  公开号：US20200317668A1

  公开（公告）日：2020-10-08

  Compounds that inhibit viral replication or the production of viral RNA or DNA or viral protein and compositions comprising such Compounds are described. Also described are methods of inhibiting or reducing viral replication or the production of viral RNA or DNA or viral protein using such Compounds, and methods for treating viral infections, such as an RNA virus belonging to the family Coronaviridae, involving the administration of such Compounds. The Compounds may be administered as a single agent therapy or in combination with one or more additional therapies to a human in need of such treatments.