N-[4-(7-Methoxy-4-methyl-3,4-dihydro-phthalazin-1-yl)-phenyl]-acetamide | 223500-32-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-[4-(7-Methoxy-4-methyl-3,4-dihydro-phthalazin-1-yl)-phenyl]-acetamide
• 英文别名: N-[4-(7-methoxy-4-methyl-3,4-dihydrophthalazin-1-yl)phenyl]acetamide
• CAS: 223500-32-1
• 化学式: C₁₈H₁₉N₃O₂
• 分子量: 309.368
• InChiKey: GUJYVODUXYUBMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  62.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-[4-(7-Methoxy-4-methyl-3,4-dihydro-phthalazin-1-yl)-phenyl]-acetamide 在 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 4-(4-Amino-phenyl)-6-methoxy-1-methyl-1H-phthalazine-2-carboxylic acid ethylamide
  参考文献：
  名称：

  Allosteric modulators of the ampa receptor: Novel 6-substituted dihydrophthalazines

  摘要：

  Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00044-x
• 作为产物：
  描述：

  4-(Benzhydrylidene-amino)-N-methoxy-N-methyl-benzamide 在 正丁基锂 、 盐酸肼 、 四甲基乙二胺 作用下， 以 四氢呋喃 、 甲醇 、 氯仿 为溶剂， 反应 2.0h， 生成 N-[4-(7-Methoxy-4-methyl-3,4-dihydro-phthalazin-1-yl)-phenyl]-acetamide
  参考文献：
  名称：

  Allosteric modulators of the ampa receptor: Novel 6-substituted dihydrophthalazines

  摘要：

  Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00044-x

文献信息

• [DE] PHTHALAZINDERIVATE, DEREN HERSTELLUNG UND VERWENDUNG ALS ARZNEIMITTEL<br/>[EN] PHTHALAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DRUGS<br/>[FR] DERIVES DE PHTALAZINE, LEUR FABRICATION ET LEUR UTILISATION COMME MEDICAMENTS
  申请人：SCHERING AKTIENGESELLSCHAFT

  公开号：WO1997040020A1

  公开（公告）日：1997-10-30

  (DE) Es werden Verbindungen der Formel (I), deren Herstellung und Verwendung als Arzneimittel beschrieben.(EN) Described are compounds of formula (I), their preparation and their use as drugs.(FR) L'invention concerne des composés de la formule (I), leur fabrication et leur utilisation comme médicaments.

  该化合物的式样(I)及其合成与使用情况已被描述。
• Allosteric modulators of the ampa receptor: Novel 6-substituted dihydrophthalazines
  作者：Xue-Feng Pei、Michael A. Sturgess、C.Fernando Valenzuela、Maria-Luisa Maccecchini

  DOI：10.1016/s0960-894x(99)00044-x

  日期：1999.2

  Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation. (C) 1999 Elsevier Science Ltd. All rights reserved.