8-Oxatricyclo[3.2.1.02,4]octane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: 8-Oxatricyclo[3.2.1.02,4]octane
• 英文别名: 8-oxatricyclo[3.2.1.02,4]octane
• 化学式: C₇H₁₀O
• 分子量: 110.15
• InChiKey: ZCFDPCSGMMTKSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Compounds and compositions for inducing chondrogenesis
  申请人：NOVARTIS AG

  公开号：US11091499B2

  公开（公告）日：2021-08-17

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.

  本发明提供了式(I)化合物或其药学上可接受的盐；(I)或其药学上可接受的盐、同系物或立体异构体，其中变量如本文所定义。本发明进一步提供了包含此类化合物的药物组合物；以及使用此类化合物治疗哺乳动物关节损伤或损伤、诱导透明软骨生成或诱导软骨祖细胞分化为成熟软骨细胞的方法。
• COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS
  申请人：NOVARTIS AG

  公开号：US20210079010A1

  公开（公告）日：2021-03-18

  The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; (I) or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds; and methods of using such compounds for treating joint damage or injury in a mammal, for inducing hyaline cartilage production or for inducing differentiation of chondrogenic progenitor cells into mature chondrocytes.