2-Methyl-4,7-epoxyisoindole-1,3-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-Methyl-4,7-epoxyisoindole-1,3-dione
• 英文别名: 2-methyl-4,7-epoxyisoindole-1,3-dione
• 化学式: C₉H₅NO₃
• 分子量: 175.14
• InChiKey: GRBGLNDOMPOVQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  50.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] DIHYDROPYRIDOPHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF<br/>[FR] DÉRIVÉ DE DIHYDROPYRIDOPHTALAZINONE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION<br/>[ZH] 二氢吡啶并酞嗪酮衍生物、其制备方法及应用
  申请人：SHANGHAI ALLIST PHARMACEUTICAL AND MEDICAL TECH CORPORATIONS

  公开号：WO2019174607A1

  公开（公告）日：2019-09-19

  本发明涉及下述通式(I)所示的二氢吡啶并酞嗪酮衍生物、其制备方法与应用，式中R1、R2、R3、m、n、环A和环B如说明书中所定义。本发明所述二氢吡啶并酞嗪酮衍生物具有良好的PARP抑制活性，可用于治疗或预防因抑制PARP活性而改善的疾病。
• NEW LIQUID HYDROCARBON COPOLYMERS COMPRISING TWO ALKOXYSILANE END GROUPS, AND PRODUCTION METHOD THEREOF
  申请人：BOSTIK SA

  公开号：US20200172660A1

  公开（公告）日：2020-06-04

  1) Hydrocarbon copolymer P comprising 2 alkoxysilane end groups F 1 and F 2 of formulae: —F 1 : (R′O) 3-t R t Si—(CH 2 ) g 1- and F 2 : —(CH 2 ) d1 —SiR t (OR′) 3-t ; or F 1 : (R′O) 3-t R t Si—R″—O(O)C—(CH 2 ) g2 — and F 2 : —(CH 2 ) d2 —C(O)O—R″—SiR t (OR″) 3-t ; wherein t is 0, 1 or 2; g1 and d1 are 1, 2 or 3; g2 and d2 are 0, 1, 2 or 3; R et R′ represent a C 1 -C 4 alkyl; R″ is a C 1 -C 4 alkylene radical; the main chain comprising motifs (I) and (II) in which R 0 is in particular the methyl radical; and the number average molecular mass Mn thereof being between 400 and 100,000 g/mol. 2) Method for producing said copolymer, comprising: (i) a step of heating a statistical bipolymer A selected from a poly(butadiene-isoprene), a poly(butadiene-myrcene) and a poly(butadiene-farnesene); and subsequently (ii) a step of heating the formed product, in the presence of a chain transfer agent of formula (C). 3) Adhesive composition comprising said copolymer.
• LIQUID HYDROCARBON COPOLYMERS HAVING TWO CYCLOCARBONATE ETHER END GROUPS
  申请人：BOSTIK SA

  公开号：US20200255571A1

  公开（公告）日：2020-08-13

  1) Hydrocarbon-based copolymer comprising two end groups preceded by an ether function and chosen from a 2-oxo-1,3-dioxolan-4-yl (or cyclocarbonate), a dithiocyclocarbonate, and a 2-oxo-1,3-dioxolen-4-yl, the main chain of which comprises units (I) and (II) in which R 0 is notably a methyl radical; and the number-average molecular mass Mn of which is between 400 and 100 000 g/mol. 2) Process for preparing said copolymer, comprising: (i) a step of heating a statistical bipolymer A chosen from a poly(butadiene-isoprene), a poly(butadiene-myrcene) and a poly(butadiene-farnesene); and then (ii) a step of heating the product formed, in the presence of a chain-transfer agent. 3) Use as adhesive, as a mixture with an amine compound comprising at least two amine groups.