6-亚甲基-6,7-二氢-1H-嘌呤 | 208994-81-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: 6-亚甲基-6,7-二氢-1H-嘌呤
• 英文名称: 6-Methylidene-6,7-dihydro-1H-purine
• 英文别名: 6-methylidene-1,7-dihydropurine
• CAS: 208994-81-4
• 化学式: C₆H₆N₄
• 分子量: 134.14
• InChiKey: JTIBTEZMCLPTAL-UHFFFAOYSA-N

物化性质

• 沸点：
  467.1±55.0 °C(Predicted)
• 密度：
  1.49±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Combinational use of mechanical manipulation and programin derivatives to increase Oct4, Sox2, Nanog or c-Myc expression in fibroblasts
  申请人：The Chinese University of Hong Kong

  公开号：US10676720B2

  公开（公告）日：2020-06-09

  The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).

  本发明提供了在已分化的哺乳动物细胞中诱导多能性的方法和组合物。特别是，这些方法包括将细胞机械地聚集成离散的团块或胚状体，并用小分子化合物处理它们。本发明提供的化合物组合物来源于程序素（如逆转录素）。
• COMBINATIONAL USE OF MECHANICAL MANIPULATION AND PROGRAMIN TO GENERATE PLURIPOTENT STEM CELLS FROM SOMATIC CELLS
  申请人：The Chinese University of Hong Kong

  公开号：US20190161738A1

  公开（公告）日：2019-05-30

  The present invention provides methods and compositions for inducing pluripotency in differentiated mammalian cells. In particular, the methods include mechanically aggregating the cells into discrete masses or embryoid-like bodies and treated them with a small molecule compound. Provided herein are the compositions of the compounds which are derived from programin (e.g., reversine).