3-Isobutyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin | 63908-37-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 3-Isobutyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin
• 英文别名: 3,7-dihydro-3-(2-methylpropyl)-1H-purine-2,6-dione；3-Isobutylxanthine；3-isobutyl-3,7(9)-dihydro-purine-2,6-dione；1H-Purine-2,6-dione, 3,7-dihydro-3-(2-methylpropyl)-；3-(2-methylpropyl)-7H-purine-2,6-dione
• CAS: 63908-37-2
• 化学式: C₉H₁₂N₄O₂
• 分子量: 208.22
• InChiKey: MUTOERQVXAXVTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  78.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5,6-diamino-1-(2-methylpropyl)-2,4-(1H,3H)-pyrimidine dione 以 sodium hydroxide 、 甲酸 、 氯仿 为溶剂， 生成 3-Isobutyl-2,6-dioxo-1,2,3,6-tetrahydro-7H-purin
  参考文献：
  名称：

  Method and pharmaceutical preparation for treating chronic obstructive

  摘要：

  一种治疗慢性阻塞性呼吸道疾病或心脏疾病的方法，其特征在于给予化合物##STR1##其中R是正丙基，正丁基或异丁基或其治疗上可接受的盐。

  公开号：

  US04325956A1

文献信息

• Theophylline-based soluble guanylyl cyclase activators KMUP-1 analogues enhanced cyclic GMP and K+ channel activities on rabbit corpus cavernosum smooth muscle and intercavernous pressure activities
  申请人：Chen Ing-Jun

  公开号：US20050209243A1

  公开（公告）日：2005-09-22

  The present invention provides the pharmaceutical compositions for relaxing corpus the cavernosal smooth muscle, increasing the intracarvernosal pressure, and enhancing learning and memory activities.

  本发明提供了用于放松海绵体平滑肌、增加海绵体内压力以及增强学习和记忆活动的药物组合物。
• Novel method for the production of differentiated respiratory epithelial cells
  申请人：Medizinische Hochschule Hannover

  公开号：EP2484754A1

  公开（公告）日：2012-08-08

  The present invention relates to a method for the production of differentiated respiratory epithelial cells comprising: (a) providing a cell population comprising or consisting of precursor cells of respiratory epithelial cells; (b) culturing the cell population of in culture medium to which keratinocyte growth factor has been added; wherein the cultured cell population is supplemented with a glucocorticoid, a cAMP analogue and a cAMP elevating agent and wherein said supplementation is either simultaneously with the addition of keratinocyte growth factor in step (b) or prior or subsequently to the addition of keratinocyte growth factor in step (b), thereby differentiating said precursor cells into respiratory epithelial cells. The present invention further relates to the cell(s) obtained by the method of the invention for use in treating or preventing a respiratory disease and to a method for identifying a compound having an pharmacological, cytotoxic, proliferative, transforming or differentiating effect on the differentiated respiratory epithelial cells obtained by the method of the invention.

  本发明涉及一种生产分化的呼吸道上皮细胞的方法，包括(a) 提供由呼吸道上皮细胞前体细胞组成的细胞群； (b) 在加入角质细胞生长因子的培养基中培养细胞群；其中，培养的细胞群补充糖皮质激素、cAMP 类似物和 cAMP 升高剂，并且所述补充与步骤(b)中添加角质形成细胞生长因子同时进行，或在步骤(b)中添加角质形成细胞生长因子之前或之后进行，从而将所述前体细胞分化为呼吸道上皮细胞。本发明还涉及通过本发明方法获得的用于治疗或预防呼吸系统疾病的细胞，以及鉴定对通过本发明方法获得的分化呼吸道上皮细胞具有药理、细胞毒性、增殖、转化或分化作用的化合物的方法。
• XANTHINE DERIVATIVE PEST CONTROL AGENTS
  申请人：THE GENERAL HOSPITAL CORPORATION

  公开号：EP0193599A1

  公开（公告）日：1986-09-10
• UTILISATION DE XANTHINES, EVENTUELLEMENT INCORPOREES DANS DES LIPOSOMES, POUR FAVORISER LA PIGMENTATION DE LA PEAU OU DES CHEVEUX
  申请人：LVMH RECHERCHE

  公开号：EP0502043B1

  公开（公告）日：1995-03-01
• RECEPTORS AND MEMBRANE-ASSOCIATED PROTEINS
  申请人：Incyte Genomics, Inc.

  公开号：EP1432801A2

  公开（公告）日：2004-06-30