(Z)-3-(2'-acetamidophenyl)-2-[1'-benzamido-2'-(3,4,5-trimethoxyphenyl)vinyl]quinazolin-4(3H)-one | 1228149-94-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: (Z)-3-(2'-acetamidophenyl)-2-[1'-benzamido-2'-(3,4,5-trimethoxyphenyl)vinyl]quinazolin-4(3H)-one
• 英文别名: N-[(Z)-1-[3-(2-acetamidophenyl)-4-oxoquinazolin-2-yl]-2-(3,4,5-trimethoxyphenyl)ethenyl]benzamide
• CAS: 1228149-94-7
• 化学式: C₃₄H₃₀N₄O₆
• 分子量: 590.635
• InChiKey: HUASNZBFMJVJFI-IMRQLAEWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  N-(2-(3,4,5-trimethoxyphenyl)-1-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)vinyl)benzamide 、 sodium acetate 、 溶剂黄146 、 邻苯二胺 反应 3.0h， 以62.2%的产率得到(Z)-3-(2'-acetamidophenyl)-2-[1'-benzamido-2'-(3,4,5-trimethoxyphenyl)vinyl]quinazolin-4(3H)-one
  参考文献：
  名称：

  Heteroannulated Quinazoline and Quinazolinone Derivatives from (Z)-2-[1-Benzamido-2-(3,4,5-trimethoxyphenyl)]vinyl-3,1-benzoxazin-4(3H)-one

  摘要：

  The title compound 1 was prepared and allowed to react with a series of nitrogen nucleophiles to afford the quinazoline and quinazolinone derivatives 2-12 and tetrazole derivative 13. The IR, 1H NMR, 13C NMR, and mass spectra of all the synthesized compounds were discussed.

  DOI：

  10.1080/00397910903098722

文献信息

• Heteroannulated Quinazoline and Quinazolinone Derivatives from (Z)-2-[1-Benzamido-2-(3,4,5-trimethoxyphenyl)]vinyl-3,1-benzoxazin-4(3H)-one
  作者：Mahmoud R. Mahmoud、Hamed A. Y. Derbala

  DOI：10.1080/00397910903098722

  日期：2010.4.26

  The title compound 1 was prepared and allowed to react with a series of nitrogen nucleophiles to afford the quinazoline and quinazolinone derivatives 2-12 and tetrazole derivative 13. The IR, 1H NMR, 13C NMR, and mass spectra of all the synthesized compounds were discussed.