Furan-2-carboxylic acid [1-(2,4-dihydroxy-phenyl)-meth-(E)-ylidene]-hydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: Furan-2-carboxylic acid [1-(2,4-dihydroxy-phenyl)-meth-(E)-ylidene]-hydrazide
• 英文别名: N'-[(2-hydroxy-4-oxocyclohexa-2,5-dien-1-ylidene)methyl]furan-2-carbohydrazide；N-[(E)-(2,4-dihydroxyphenyl)methylideneamino]furan-2-carboxamide
• 化学式: C₁₂H₁₀N₂O₄
• 分子量: 246.222
• InChiKey: OZYMOWRUCWVBSL-NTUHNPAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  95.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-呋喃甲酰肼 、 2,4-二羟基苯甲醛 以 N,N-二甲基甲酰胺 为溶剂， 生成 Furan-2-carboxylic acid [1-(2,4-dihydroxy-phenyl)-meth-(E)-ylidene]-hydrazide
  参考文献：
  名称：

  Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

  摘要：

  A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.09.058

文献信息

• Design, synthesis and in vitro antimalarial activity of an acylhydrazone library
  作者：Patricia Melnyk、Virginie Leroux、Christian Sergheraert、Philippe Grellier

  DOI：10.1016/j.bmcl.2005.09.058

  日期：2006.1

  A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators. (c) 2005 Elsevier Ltd. All rights reserved.