4-chloro-N-(1,3-dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4-chloro-N-(1,3-dioxooctahydro-4,6-ethenocyclopropa[f]isoindol-2(1H)-yl)benzamide
• 英文别名: 4-chloro-N-(3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl)benzamide
• 化学式: C₁₈H₁₅ClN₂O₃
• mdl: MFCD00686257
• 分子量: 342.8
• InChiKey: USPKYYZDABFFSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  66.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES
  申请人：Siga Technologies, Inc.

  公开号：EP3006425A1

  公开（公告）日：2016-04-13

  Pharmaceutical compositions containing di, tri, and tetracyclic acylhydrazide derivatives of the formula below, for use in the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  含有以下结构的二、三和四环脂肼衍生物的药物组合物，用于治疗或预防病毒感染及相关疾病，特别是由正痘病毒引起的那些病毒感染和相关疾病。
• [EN] COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PREVENTION OF ORTHOPOXVIRUS INFECTIONS AND ASSOCIATED DISEASES<br/>[FR] COMPOSES, COMPOSITIONS ET PROCEDES PERMETTANT DE TRAITER ET DE PREVENIR DES INFECTIONS A ORTHOPOXVIRUS ET DES MALADIES ASSOCIEES
  申请人：VIROPHARMA INC

  公开号：WO2004112718A2

  公开（公告）日：2004-12-29

  Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

  使用二、三、四环酰肼衍生物及类似物的方法，以及含有其的药物组合物，用于治疗或预防病毒感染及其相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。
• Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
  申请人：Jordan Robert

  公开号：US20060235051A1

  公开（公告）日：2006-10-19

  Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

  使用二、三、四环脂肪酰肼衍生物及其类似物的方法，以及包含它们的药物组合物，用于治疗或预防病毒感染及其相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。
• Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases
  申请人：Jordan F. Robert

  公开号：US20070287735A1

  公开（公告）日：2007-12-13

  Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases cased by the orthopoxvirus.

  使用二、三和四环戊二酰肼衍生物及类似物的方法，以及含有它们的药物组合物，用于治疗或预防病毒感染及其相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。
• Compounds, Compositions and Methods for Treatment and Prevention of Orthopoxvirus Infections and Associated Diseases
  申请人：Jordan Robert

  公开号：US20100227892A1

  公开（公告）日：2010-09-09

  Methods of using di, tri, and tetracyclic acylhydrazide derivatives and analogs, as well as pharmaceutical compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.

  使用二、三、四环腈肟衍生物及其类似物的方法，以及含有它们的制药组合物，用于治疗或预防病毒感染及其相关疾病，特别是由正痘病毒引起的病毒感染和相关疾病。