3-{[2-hydroxy-3-(10H-phenothiazin-10-yl)propyl]amino}propan-1-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3-{[2-hydroxy-3-(10H-phenothiazin-10-yl)propyl]amino}propan-1-ol
• 英文别名: 1-(3-hydroxypropylamino)-3-phenothiazin-10-ylpropan-2-ol
• 化学式: C₁₈H₂₂N₂O₂S
• 分子量: 330.4
• InChiKey: WTKGATGXKIDLBE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  23
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• CDKI PATHWAY INHIBITORS AND USES THEREOF
  申请人：Chang Bey-Dih

  公开号：US20090281129A1

  公开（公告）日：2009-11-12

  The invention relates to the inhibition of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to methods for inhibiting the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.
• CDKI Pathway inhibitors and uses thereof to regulate expression to TAU protein
  申请人：Porter Donald

  公开号：US20100190807A1

  公开（公告）日：2010-07-29

  The invention relates to the inhibition of the Cyclin-Dependent Kinase Inhibitor (CDKI) pathway. More particularly, the invention relates to methods for inhibiting increases in MAPT expression induced by the CDKI pathway for studies of and intervention in senescence-related and other CDKI-related diseases.