1-(1-ethylazetidin-3-yl)-N-methylmethanamine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氮杂环丁烷
• 英文名称: 1-(1-ethylazetidin-3-yl)-N-methylmethanamine
• 化学式: C₇H₁₆N₂
• 分子量: 128.22
• InChiKey: VKVURHAGJKDHAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  15.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Tetrahydropyrazolopyrimidine compounds
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US11130758B2

  公开（公告）日：2021-09-28

  Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.

  本公开的实施方案涉及作为Toll样受体7和/或8的拮抗剂或抑制剂的四氢吡唑嘧啶化合物，以及它们在有效治疗系统性红斑狼疮（SLE）和狼疮肾炎的药物组合物中的用途。
• TETRAHYDROPYRAZOLOPYRIMIDINE COMPOUNDS
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US20200347050A1

  公开（公告）日：2020-11-05

  Embodiments of the disclosure relate to tetrahydropyrazolopyrimidine compounds that act as antagonists or inhibitors for Toll-like receptors 7 and/or 8, and their use in pharmaceutical compositions effective for treatment of systemic lupus erythematosus (SLE) and lupus nephritis.
• [EN] FUSED QUADRACYCLIC COMPOUNDS, COMPOSITIONS AND USES THEREOF<br/>[FR] COMPOSÉS QUADRACYCLIQUES CONDENSÉS, COMPOSITIONS ET UTILISATIONS ASSOCIÉES
  申请人：TABOMEDEX BIOSCIENCES LLC

  公开号：WO2017120164A1

  公开（公告）日：2017-07-13

  Provided herein are substituted fused quadracyclic compounds useful as inhibitors of MK2. The invention further provides pharmaceutical compositions of the compounds of the invention. The invention also provides medical uses of substituted fused quadracyclic compounds.