2-[4-(1,3-dioxoisoindol-2-yl)butanoylamino]-N-(oxolan-2-ylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-[4-(1,3-dioxoisoindol-2-yl)butanoylamino]-N-(oxolan-2-ylmethyl)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxamide
• 化学式: C₂₅H₂₇N₃O₅S
• 分子量: 481.6
• InChiKey: WRMBJPYIKWVPKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  133
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• MOLECULES INHIBANT UNE VOIE METABOLIQUE IMPLIQUANT LA PROTEINE TYROSINE KINASE SYK ET PROCEDE D'IDENTIFICATION DE CES MOLECULES
  申请人：Centre National de la Recherche Scientifique

  公开号：EP2285366B1

  公开（公告）日：2015-02-25
• MOLECULES INHIBITING A METABOLIC PATHWAY INVOLVING THE SYK PROTEIN TYROSINE KINASE AND METHOD FOR IDENTIFYING SAID MOLECULES
  申请人：Dariavach Piona

  公开号：US20110112098A1

  公开（公告）日：2011-05-12

  The present invention relates to the C-13 molecule (methyl 2-5-[(3-benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]-2-furyl}-benzoate) and to organic molecules functionally equivalent to the C-13 molecule, capable of inhibiting the binding of an antibody or antibody fragment with the human Syk protein tyrosine kinase, to the use of these molecules for the production of medicaments for the prevention or treatment of diseases dependent on metabolic pathways involving Syk, and also to a method for identifying such molecules.
• US9504676B2
  申请人：——

  公开号：US9504676B2

  公开（公告）日：2016-11-29