9-(4-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine | 1236360-31-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-(4-azido-2-deoxy-2-fluoro-b-D-arabinofuranosyl)-9H-purin-6-amine
• 英文别名: 9-(4-azido-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine；(2R,3R,4S,5R)-5-(6-aminopurin-9-yl)-2-azido-4-fluoro-2-(hydroxymethyl)oxolan-3-ol
• CAS: 1236360-31-8
• 化学式: C₁₀H₁₁FN₈O₃
• 分子量: 310.248
• InChiKey: KADVHRGBDQISRB-ZGGCGKHDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  134
• 氢给体数：
  3
• 氢受体数：
  10

文献信息

• ANTIVIRAL AGENTS
  申请人：Surnma Vincenzo

  公开号：US20120010164A1

  公开（公告）日：2012-01-12

  Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; as defined herein, are described for use in the prevention and/or treatment of HCV infections. Novel compounds of the formula (I) and pharmaceutical formulations containing them are also described.

  结构式（I）的化合物及其药用盐；如本文所定义，用于预防和/或治疗HCV感染。还描述了公式（I）的新化合物以及含有它们的药物配方。
• [EN] ANTIVIRAL AGENTS<br/>[FR] AGENTS ANTIVIRAUX
  申请人：ANGELETTI P IST RICHERCHE BIO

  公开号：WO2010084115A2

  公开（公告）日：2010-07-29

  Compounds of structural formula (I): and pharmaceutically acceptable salts thereof; as defined herein, are described for use in the prevention and/or treatment of HCV infections. Novel compounds of the formula (I) and pharmaceutical formulations containing them are also described.