1-[(2R,5S)-4-azido-5-(phosphanyloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 1-[(2R,5S)-4-azido-5-(phosphanyloxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione
• 化学式: C10H14N5O4P
• 分子量: 299.22
• InChiKey: ZZODCKCKPMGNRP-SPDVFEMOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  82.2
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• MODIFIED 5'- PHOSPHONATE AZIDOTHYMIDINE-POTENTIAL ANTI-VIRAL PREPARATIONS
  申请人：Khokhlov, Alexander Fedorovich

  公开号：EP1829885B1

  公开（公告）日：2015-07-15
• MODIFIED 5'- PHOSPHONATE AZIDOTHYMIDINE - POTENTIAL ANTI-VIRAL PREPARATIONS
  申请人：Kukhanova Marina Konstantinovna

  公开号：US20090111979A1

  公开（公告）日：2009-04-30

  The invention relates to the field of molecular biology, virology and medicine and, more specifically, to novel derivatives of 3′-azido-3′-deoxythymidine phosphonates with the following general formula where R=alkyl groups, including those containing halogen atoms, carboxy-, hydroxy-, alkoxy- and acyloxy- groups as well as substituted aminocarbonyl groups. The compounds can be used as antiviral agents as they have low toxicity and can effectively inhibit replication of type 1 immunodeficiency virus in MT-4 cell culture and generate AZT in mammalians ensuring a gradual increase of its concentration in the blood.
• US7999099B2
  申请人：——

  公开号：US7999099B2

  公开（公告）日：2011-08-16