(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol
• 英文别名: (1-(Tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol；[1-(oxan-2-yl)pyrazol-3-yl]methanol
• 化学式: C₉H₁₄N₂O₂
• 分子量: 182.222
• InChiKey: SMIPNLAKFIFKSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  47.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol 生成 N-((5-((1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methoxy)-1-(4-(trifluoromethyl)phenyl)-1H-indazol-3-yl)methyl)methanesulfonamide
  参考文献：
  名称：

  Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  US20230202985A1
• 作为产物：
  描述：

  1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazole-3-carbaldehyde 在 甲醇 、 sodium tetrahydroborate 作用下， 生成 (1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-3-yl)methanol
  参考文献：
  名称：

  Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  US20230202985A1

文献信息

• SUBSTITUTED GUANIDINE DERIVATIVE
  申请人：UBE Industries, Ltd.

  公开号：EP3333163A1

  公开（公告）日：2018-06-13

  The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

  本发明提供了通式（I）的化合物（其中，R1、X、p 和 q 如本说明书和权利要求书所述）或其药理学上可接受的盐，以及含有该化合物的药物组合物。
• Substituted guanidine derivatives
  申请人：UBE INDUSTRIES, LTD.

  公开号：US10759781B2

  公开（公告）日：2020-09-01

  The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

  本发明提供了通式（I）的化合物（其中，R1、X、p 和 q 如本说明书和权利要求书所述）或其药理学上可接受的盐，以及含有该化合物的药物组合物。
• EP3333163
  申请人：——

  公开号：——

  公开（公告）日：——
• WO2020023710A5
  申请人：——

  公开号：WO2020023710A5

  公开（公告）日：2022-08-01
• SUBSTITUTED GUANIDINE DERIVATIVES
  申请人：UBE INDUSTRIES, LTD.

  公开号：US20190152953A1

  公开（公告）日：2019-05-23

  The present invention provides a compound of general formula (I) (wherein, R 1 , X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.