(E)-1-phenyl-2-(1-(4-chlorophenyl)-1,3-diphenylazetidin-2-ylidene)ethanone | 1246658-15-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-1-phenyl-2-(1-(4-chlorophenyl)-1,3-diphenylazetidin-2-ylidene)ethanone
• 英文别名: (2E)-2-[1-(4-chlorophenyl)-3,4-diphenylazetidin-2-ylidene]-1-phenylethanone
• CAS: 1246658-15-0
• 化学式: C₂₉H₂₂ClNO
• 分子量: 435.953
• InChiKey: WSVYJLBLMUOSQC-LHLOQNFPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-亚苄基-4-氯苯胺 、 (2,2-difluoro-3-phenylcyclopropyl)(phenyl)methanone 在 magnesium iodide 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以66%的产率得到(E)-1-phenyl-2-(1-(4-chlorophenyl)-1,3-diphenylazetidin-2-ylidene)ethanone
  参考文献：
  名称：

  Magnesium iodide promoted defluorinative reactions of 2,2-difluorocyclopropyl aryl ketones with aryl imines: A new, general synthesis of 2-alkylideneazetidines

  摘要：

  Upon treatment with anhydrous MgI2, 2,2-difluorocyclopropyl aryl ketones undergo a ring-opening process leading to complete loss of fluorine. When carried out in the presence of aryl imines, the reaction leads to a novel synthesis of 2-alkylideneazetidenes. A fluorine-free allenyl ketone is proposed as an intermediate in these reactions. (C) 2010 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2010.06.021

文献信息

• Magnesium iodide promoted defluorinative reactions of 2,2-difluorocyclopropyl aryl ketones with aryl imines: A new, general synthesis of 2-alkylideneazetidines
  作者：Wei Xu、Ion Ghiviriga、Qing-Yun Chen、William R. Dolbier

  DOI：10.1016/j.jfluchem.2010.06.021

  日期：2010.9

  Upon treatment with anhydrous MgI2, 2,2-difluorocyclopropyl aryl ketones undergo a ring-opening process leading to complete loss of fluorine. When carried out in the presence of aryl imines, the reaction leads to a novel synthesis of 2-alkylideneazetidenes. A fluorine-free allenyl ketone is proposed as an intermediate in these reactions. (C) 2010 Published by Elsevier B.V.