2,6-Bis-(2-hydroxy-ethoxymethyl)-1,1-dioxo-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 英文名称: 2,6-Bis-(2-hydroxy-ethoxymethyl)-1,1-dioxo-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one
• 英文别名: 2,6-Bis(2-hydroxyethoxymethyl)-1,1-dioxo-1,2,6-thiadiazin-3-one
• 化学式: C₉H₁₆N₂O₇S
• 分子量: 296.301
• InChiKey: UBSKEXSLSAZMGS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  叔丁基二甲基氯硅烷 、 2,6-Bis-(2-hydroxy-ethoxymethyl)-1,1-dioxo-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one 在 吡啶 、 咪唑 作用下， 以 二氯甲烷 为溶剂， 反应 7.0h， 以76%的产率得到2,6-Bis-[2-(tert-butyl-dimethyl-silanyloxy)-ethoxymethyl]-1,1-dioxo-1,6-dihydro-2H-1λ⁶-[1,2,6]thiadiazin-3-one
  参考文献：
  名称：

  Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides

  摘要：

  Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.

  DOI：

  10.1080/07328319708001347

文献信息

• Synthesis and Antiviral Activity of Modified 1,2,6-Thiadiazine Dioxide Acyclonucleosides
  作者：A. I. Esteban、E. De Clercq、A. Martinez

  DOI：10.1080/07328319708001347

  日期：1997.3

  Modified 1,2,6-thiadiazine dioxide acyclonucleosides were synthesized using the silylation method. All the compounds were tested as antiviral agents in a wide variety of assay systems. With two compounds, some activity (20, 35 and 14 mu g/mL, respectively) was noted against herpes simplex virus, human cytomegalovirus and varicella-zoster virus.