ethyl 4-[(5,6,7,8-tetrahydro-5-hydroxy-8,8-dimethylnaphth-3-yl)ethynyl]benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: ethyl 4-[(5,6,7,8-tetrahydro-5-hydroxy-8,8-dimethylnaphth-3-yl)ethynyl]benzoate
• 英文别名: ethyl 4-[2-(8-hydroxy-5,5-dimethyl-7,8-dihydro-6H-naphthalen-2-yl)ethynyl]benzoate
• 化学式: C₂₃H₂₄O₃
• 分子量: 348.442
• InChiKey: RKAVXDSAMZQAFH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-[(5,6,7,8-四氢-5,5-二甲基-8-氧代-2-萘)乙炔]苯甲酸乙酯 在 sodium borohydrid 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 生成 ethyl 4-[(5,6,7,8-tetrahydro-5-hydroxy-8,8-dimethylnaphth-3-yl)ethynyl]benzoate
  参考文献：
  名称：

  Method for inhibiting gene expression promoted by AP1 protein with

  摘要：

  抑制由AP1蛋白促进的基因表达，但不显著激活在其启动子区域中具有RA响应元件的基因表达（通过RAR.alpha和RAR.GAMMA受体亚型），可用于治疗对维甲酸类药物治疗产生响应的疾病和症状，且具有减少副作用。

  公开号：

  US06025388A1

文献信息

• Substituted acetylenes having retinoid-like biological activity
  申请人：Allergan

  公开号：US05648514A1

  公开（公告）日：1997-07-15

  Compounds of the formula ##STR1## wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.

  式子为##STR1##的化合物，其中符号的含义在说明书中描述，具有类似于视黄醇的生物活性。
• Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group
  申请人：Allergan

  公开号：US05654469A1

  公开（公告）日：1997-08-05

  Compounds of Formula I ##STR1## wherein the symbols are as defined in the specification.

  式I的化合物##STR1## 其中符号如规范中所定义。
• Acetylenes disubstituted with a 5 alkyl, aryl or heteroaryl substituted
  申请人：Allergan Sales, Inc.

  公开号：US05998471A1

  公开（公告）日：1999-12-07

  Compounds of the formula ##STR1## the symbols have the meaning described in the specification.

  式子为##STR1##的化合物，其中符号的含义在说明书中描述。
• ACETYLENES DISUBSTITUTED WITH A 5 ALKYL, ARYL OR HETEROARYL SUBSTITUTED DIHYDRONAPHTHYL GROUP AND WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE WITH AN ARYL OR HETEROARYL GROUP HAVING RETINOID-LIKE BIOLOGICAL ACTIVITY
  申请人：Allergen Sales, Inc.

  公开号：US06355806B1

  公开（公告）日：2002-03-12

  Compounds of the formula wherein the symbols have the meaning described in the specification, have retinoid-like biological activity.

  式中符号的含义如规范所述，具有类视黄醇生物活性的化合物。
• Method for inhibiting gene expression promoted by AP1 protein with RAR&bgr; selective retinoids and method for treatment of diseases and conditions with such retinoids
  申请人：Allergan Sales, Inc.

  公开号：US06369100B1

  公开（公告）日：2002-04-09

  Retinoid compounds which repress expression of the gene promoted by AP1 protein but which do not significantly activate expression of the genes having RA-responsive elements in their promoter region through RAR&agr; and RAR&Ggr; receptor subtypes, are used, with reduced side effects, for treating diseases and conditions which are responsive to therapy with retinoids.

  使用抑制AP1蛋白促进基因表达的视黄醇类化合物，但不通过RARα和RARγ受体亚型显著激活其启动子区域中具有RA响应元素的基因的表达，可用于治疗对视黄醇疗法有反应的疾病和病况，具有减少副作用的效果。