2-(3-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)-N,N-dimethylethanamine hydrochloride | 458151-58-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2-(3-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)-N,N-dimethylethanamine hydrochloride
• 英文别名: 1-[2-(Dimethylamino)ethyl]-3-(2,5-dioxo-3,4-diphenylpyrrol-1-yl)piperidine-2,6-dione;hydrochloride
• CAS: 458151-58-1
• 化学式: C₂₅H₂₅N₃O₄*ClH
• 分子量: 467.952
• InChiKey: WRNAGSZXUUVNLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.47
• 重原子数：
  33
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  78
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  1-(2,6-dioxotetrahydro-2H-pyran-3-yl)-3,4-diphenyl-1H-pyrrole-2,5-dione 、 N,N-二甲基乙二胺 在 乙酸酐 、 乙酰氯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 26.5h， 以88%的产率得到2-(3-(2,5-dioxo-3,4-diphenyl-2,5-dihydro-1H-pyrrol-1-yl)-2,6-dioxopiperidin-1-yl)-N,N-dimethylethanamine hydrochloride
  参考文献：
  名称：

  Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-α production

  摘要：

  A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-alpha production. These derivatives enhance TNF-a production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-alpha production induced with okadaic acid (OA) in the same cell line. The diphenylmaleimide derivative 2f, was found to be the most active product, producing a strong modulation of the cytokine level. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.03.018

文献信息

• Discovering a new analogue of thalidomide which may be used as a potent modulator of TNF-α production
  作者：Miguel Fernández Braña、Nuria Acero、Loreto Añorbe、Dolores Muñoz Mingarro、Francisco Llinares、Gema Domínguez

  DOI：10.1016/j.ejmech.2009.03.018

  日期：2009.9

  A new series of imide derivatives related to thalidomide were synthesized and evaluated as modulators of TNF-alpha production. These derivatives enhance TNF-a production using human leukemia HL-60 cells induced with 12-O-tetradecanoylphorbol 13-acetate (TPA), while inhibiting TNF-alpha production induced with okadaic acid (OA) in the same cell line. The diphenylmaleimide derivative 2f, was found to be the most active product, producing a strong modulation of the cytokine level. (C) 2009 Elsevier Masson SAS. All rights reserved.