N-[2-(N',N'-diethylamino)ethyl]-10H-phenothiazine-10-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: N-[2-(N',N'-diethylamino)ethyl]-10H-phenothiazine-10-carboxamide
• 英文别名: phenothiazine-10-carboxylic acid-(2-diethylamino-ethylamide)；Phenothiazin-10-carbonsaeure-(2-diaethylamino-aethylamid)；N-[2-(diethylamino)ethyl]-10H-phenothiazine-10-carboxamide；N-[2-(diethylamino)ethyl]phenothiazine-10-carboxamide
• 化学式: C₁₉H₂₃N₃OS
• 分子量: 341.477
• InChiKey: QSJQKFPGHYDDTM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  60.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] NOVEL N-SUBSTITUTED PHENOTHIAZINES AND THEIR USE AS MODULATORS OF SERINE HYDROLASE ENZYMES<br/>[FR] NOUVELLES PHENOTHIAZINES N-SUBSTITUEES ET LEUR UTILISATION EN TANT QUE MODULATEUR D'ENZYME HYDROLASES A SERINE
  申请人：UNIV DALHOUSIE

  公开号：WO2001092240A1

  公开（公告）日：2001-12-06

  The present invention is directed to phenothiazine compounds of formula (I), wherein R is: (a) a branched or straight chain (C1-C6)alkyl group unsubstituted or substituted by phenyl, halo or -NR1R2, wherein R1 and R2 are independently H, a branched or straight chain (C1-C6)alkyl group or R1 and R2 together with the nitrogen atom to which they are bonded form a 5- or 6-membered ring; (b) phenyl; or (c) -NR3R4, wherein R3 and R4 are independently; (i) H, (ii) a branched or straight chain (C1-C6)alkyl group unsubstituted or substituted by (C1-C4)alkoxy, phenyl or -NR5R6, wherein R5 and R6 are independently H, a branched or straight chain (C1-C¿4)alkyl group, phenothiazine carbonyl or R5 and R6 taken together with the nitrogen atom to which they are bonded form a 5- or 6-membered ring; (v) a (C5-C6)cycloalkyl group; or (iv) R3 and R4 together with the nitrogen atom to which they are bonded form pyrrolidino, piperidino, morpholino, piperazino or 4-methylpiperazino, or a pharmacologically acceptable salt thereof, for use in the treatment of Alzheimer's disease and other conditions. Compounds of formula (I) modulate the activity of serine hydrolase enzymes, for example, they are cholinesterase inhibitors.