9-Methylthioadenine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 9-Methylthioadenine
• 英文别名: 9-methylsulfanylpurin-6-amine
• 化学式: C₆H₇N₅S
• 分子量: 181.22
• InChiKey: XKJYEVSFMVZEIK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  94.9
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• ANTICANCER MICRORNA AND LIPID FORMULATIONS THEREOF
  申请人：INTERNA TECHNOLOGIES B.V.

  公开号：US20210038732A1

  公开（公告）日：2021-02-11

  The present invention relates to a lipid formulation comprising microRNA. The formulation comprises cationic lipids that can form lipid nanoparticles with the microRNA. The formulations are useful in medicine.

  本发明涉及一种含有微RNA的脂质配方。该配方包括能与微RNA形成脂质纳米粒子的阳离子脂质。这些配方在医学上很有用。
• [EN] AN IMMUNOREACTIVE 38-KDA FERRIC BINDING PROTEIN OF EHRLICHIA CANIS AND USES THEREOF<br/>[FR] PROTEINE DE LIAISON FERRIQUE 38-KDA IMMUNOREACTIVE DE EHRLICHIA CANIS ET SON UTILISATION
  申请人：RES DEV FOUNDATION

  公开号：WO2005082930A2

  公开（公告）日：2005-09-09

  The present invention is directed to the cloning, sequencing, expression, and characterization of an immunoreactive ferric. binding protein (Fbp) (38-kDa) protein of Ehrlichia canis encoded by a polynucleotide therefor. In particular embodiments, the protein is employed in an immunogenic composition, such as a vaccine. Methods to induce an immune reaction in an individual with compositions of the invention are provided.

  本发明涉及克隆、测序、表达和表征由Ehrlichia canis的多核苷酸编码的一种免疫反应性铁结合蛋白（Fbp）（38-kDa）蛋白质。在特定实施例中，该蛋白质被用于免疫原性组合物，例如疫苗。本发明提供了使用该组合物诱导个体免疫反应的方法。
• Polymer combinations that result in stabilized aerosols for gene delivery to the lungs
  申请人：——

  公开号：US20020187105A1

  公开（公告）日：2002-12-12

  The use of non-viral delivery of therapeutically effective compositions through aerosol for therapy or research purpose has been limited by the low efficiency mainly caused by an inefficient delivery system and destruction of formulation (gene and/or delivery system) by aerosol shearing power. This invention develops formulations that are established polymer combination formulations. The formulations are highly efficient in delivering genes in vivo through aerosol and are able to protect the delivered gene from the destruction by aerosol shearing power.

  非病毒递送疗效成分通过气溶胶用于治疗或研究目的的使用受到限制，主要是由于递送系统效率低和气溶胶剪切力破坏制剂（基因和/或递送系统）所致。本发明开发了一种确定的聚合物组合制剂，该制剂在体内通过气溶胶高效递送基因，并能保护递送的基因免受气溶胶剪切力的破坏。
• PEI: DNA vector formulations for in vitro and in vivo gene delivery
  申请人：Board of Regents, The University of Texas System

  公开号：US20020151060A1

  公开（公告）日：2002-10-17

  The present invention relates generally to the fields of nucleic acid transfection. More particularly, it concerns novel polycation:nucleic acid compositions, methods of preparation of such compositions and methods of transfecting cells with such compositions.

  本发明通常涉及核酸转染领域。更具体地说，涉及新型多阳离子：核酸组合物的制备方法，以及使用这种组合物转染细胞的方法。
• Ginkgo biloba levopimaradiene synthase
  申请人：——

  公开号：US20020164736A1

  公开（公告）日：2002-11-07

  The present invention is directed to nucleic acid sequences of Ginkgo biloba diterpene synthases, particularly of a levopimaradiene synthase. More specifically, the invention is directed to a cell of a unicellular organism, such as Saccharomyces cerevisiae or Escherichia coli , comprising levopimaradiene synthase for the metabolically engineered in vivo biosynthesis of a diterpene and a ginkgolide.

  本发明涉及银杏二萜合成酶的核酸序列，特别是左旋油松烯合成酶。更具体地说，本发明涉及单细胞生物（如酿酒酵母或大肠杆菌）的细胞，包括左旋油松烯合成酶，用于代谢工程中体内生物合成二萜类化合物和银杏内酯的方法。