N-(6-aminohexyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carboxamide

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: N-(6-aminohexyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2,4-dioxopyrimidine-5-carboxamide
• 化学式: C₁₆H₂₆N₄O₆
• 分子量: 370.4
• InChiKey: GUUJLNMLJJCWCF-YNEHKIRRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  154
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Aptamers with binding affinity to norovirus
  申请人：North Carolina State University

  公开号：US10308989B2

  公开（公告）日：2019-06-04

  The instant disclosure provides norovirus binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.

  本公开提供了诺如病毒结合适配体、包含这种适配体的组合物以及使用和生产这种适配体的方法。这些适配体可用于检测测试样本中是否存在诺如病毒、捕获和/或浓缩测试样本中的诺如病毒、评估治疗剂对诊断为诺如病毒感染的患者的疗效以及评估诺如病毒疫苗的疗效。
• APTAMERS WITH BINDING AFFINITY TO NOROVIRUS
  申请人：North Carolina State University

  公开号：US20170114420A1

  公开（公告）日：2017-04-27

  The instant disclosure provides norovirus -binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.
• [EN] APTAMERS WITH BINDING AFFINITY TO NOROVIRUS<br/>[FR] APTAMÈRES AYANT UNE AFFINITÉ DE LIAISON À UN NOROVIRUS
  申请人：UNIV NORTH CAROLINA STATE

  公开号：WO2015192050A1

  公开（公告）日：2015-12-17

  The instant disclosure provides norovirus-binding aptamers, compositions comprising such aptamers, and methods of using and producing such aptamers. The aptamers are useful, for example, for detecting the presence of norovirus in test samples, for capturing and/or concentrating norovirus from test samples, for evaluating the efficacy of therapeutic agents in patients diagnosed with a norovirus infection, and for evaluating the efficacy of norovirus vaccines.