6-氯-9-硝基-5-氧代-5H-苯并[a]吩恶嗪 | 73397-12-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶嗪类
• 中文名称: 6-氯-9-硝基-5-氧代-5H-苯并[a]吩恶嗪
• 英文名称: 6-chloro-9-nitro-5H-benzophenoxazin-5-one
• 英文别名: SB/ZW/0031；6-chloro-9-nitro-benzo[a]phenoxazin-5-one；6-Chlor-9-nitro-benzo[a]phenoxazin-5-on；6-chloro-9-nitro-5-oxo-5H-benzo[a]phenoxazine；9-nitro-6-chlorobenzo[a]phenoxazin-5-one；6-chloro-9-nitrobenzo[a]phenoxazin-5-one
• CAS: 73397-12-3
• 化学式: C₁₆H₇ClN₂O₄
• 分子量: 326.696
• InChiKey: ORQQSXRWRGYETD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  23
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.5
• 氢给体数：
  0
• 氢受体数：
  5

SDS

反应信息

• 作为产物：
  描述：

  2,3-二氯-1,4-萘醌 、 2-氨基-5-硝基苯酚 在 乙醇 、 sodium acetate 作用下， 生成 6-氯-9-硝基-5-氧代-5H-苯并[a]吩恶嗪
  参考文献：
  名称：

  Condensation product of the oxazine series

  摘要：

  公开号：

  US02020651A1

文献信息

• [EN] REMOVAL OF SENESCENCE-ASSOCIATED MACROPHAGES<br/>[FR] ÉLIMINATION DE MACROPHAGES ASSOCIÉS À LA SÉNESCENCE
  申请人：EVERON BIOSCIENCES INC

  公开号：WO2017189553A1

  公开（公告）日：2017-11-02

  In various aspects and embodiments provided are compounds, compositions and methods relating to aging, senescent cells (SCs) and/or senescence associate macrophages (SAMs). In certain aspects and embodiments provided are compounds and compositions that selectively kill or reprogram senescent cells (SCs) and or senescence associate macrophages (SAMs) and associated methods. In some embodiments, the compounds compositions and methods treat or reverse aging and/or age-related diseases.

  在提供的各种方面和实施例中，涉及与衰老、衰老细胞（SCs）和/或衰老相关巨噬细胞（SAMs）有关的化合物、组合物和方法。在某些方面和实施例中，提供了选择性杀死或重新编程衰老细胞（SCs）和/或衰老相关巨噬细胞（SAMs）的化合物和组合物以及相关方法。在一些实施例中，这些化合物、组合物和方法用于治疗或逆转衰老和/或与年龄相关的疾病。
• Novel phenoxazinone derivatives as enzyme substrates and use thereof as indicator in the detection of microorganisms with peptidase activity
  申请人：James Arthur

  公开号：US20060121551A1

  公开（公告）日：2006-06-08

  The present invention relates to novel enzymatic substrates with the following general formula: where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , A and X are as defined in claim 1, the reaction media comprising the same and the use thereof for the detection and/or identification and/or quantification of microorganisms expressing at least one peptidase activity.

  本发明涉及具有以下一般公式的新型酶底物：其中R1、R2、R3、R4、R5、R6、A和X如权利要求1所定义，反应介质包括相同的成分以及其用于检测和/或鉴定和/或定量表达至少一种肽酶活性的微生物的用途。
• Method for the Fluorescent Detection of Nitroreductase Activity Using Nitro-Substituted Aromatic Compounds
  申请人：Smaill Jeffrey B.

  公开号：US20100173332A1

  公开（公告）日：2010-07-08

  A method utilising one or more fluorogenic probes, for the detection of nitroreductase activity. The non-fluorescent probes are reduced in the presence of nitroreductase to form fluorescent derivatives that may be detected using fluorescence spectroscopy. In particular, the method may be used to detect and/or identify a plurality of nitroreductase in a single test environment

  一种利用一个或多个荧光探针检测硝基还原酶活性的方法。非荧光探针在硝基还原酶存在下被还原成荧光衍生物，可以使用荧光光谱法检测。特别地，该方法可用于在单个测试环境中检测和/或鉴定多种硝基还原酶。
• [EN] COMPOUNDS AND METHODS FOR SELECTIVE IMAGING AND/OR ABLATION<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR L'IMAGERIE ET/OU L'ABLATION SÉLECTIVES
  申请人：AUCKLAND UNISERVICES LTD

  公开号：WO2014007650A1

  公开（公告）日：2014-01-09

  The invention relates generally to compounds and methods for imaging and/or selective ablation of nitroreductase-expressing cells and/or biological agents. More particularly, although not exclusively, the invention provides compounds that are selectively metabolised by bacterial nitroreductases and are substantially insensitive to metabolism under oxic or hypoxic conditions by human nitroreductase enzymes.

  本发明涉及一般化合物和方法，用于成像和/或选择性消融硝基还原酶表达细胞和/或生物制剂。更具体地，尽管不是唯一的，本发明提供了一些选择性被细菌硝基还原酶代谢并且在氧化或缺氧条件下对人体硝基还原酶酶不敏感的化合物。
• Self-immolative probes for enzyme activity detection
  申请人：Szczepanik Maciej

  公开号：US20120122136A1

  公开（公告）日：2012-05-17

  Provided is a compound comprising the structure: (SIG)-(SI-MOD) m . In this compound, SIG is a signaling molecule, SI is a self-immolative structure bound to SIG such that SIG has a reduced signal relative to the signal of SIG without SI, MOD is a moiety bound to SI that is subject to modification by an activator, and m is an integer from 1 to about 10. With this compound, when MOD is modified by an activator, SI is destabilized and self-cleaved from SIG such that SIG generates an increased signal. Also provided is a method of determining whether a sample comprises an activator, using the above-described compound. Additionally provided is a method of determining whether a cell comprises a nitroreductase using the above-described compound where nitroreductase is the activator. Further provided is a method of determining whether a mammalian cell is hypoxic using the above-described compound where nitroreductase is the activator. A method of detecting a microorganism that comprises a nitroreductase, using the above-described compound where nitroreductase is the activator, is also provided. Also provided is a method of identifying nitroreductase in a sample, using the above-described compound where nitroreductase is the activator.

  提供的是一种化合物，包括结构：(SIG)-(SI-MOD)m。在该化合物中，SIG是一种信号分子，SI是结合在SIG上的自解离结构，使得SIG的信号相对于没有SI的SIG降低，MOD是结合在SI上的一种基团，可被活化剂修饰，m是1到约10的整数。使用这种化合物，当MOD被活化剂修饰时，SI被不稳定化并从SIG中自我裂解，从而使SIG产生增加的信号。还提供了一种使用上述化合物确定样品是否包含活化剂的方法。此外，还提供了一种使用上述化合物确定细胞是否包含硝基还原酶的方法，其中硝基还原酶是活化剂。还提供了一种使用上述化合物确定哺乳动物细胞是否低氧的方法，其中硝基还原酶是活化剂。还提供了一种使用上述化合物检测包含硝基还原酶的微生物的方法，其中硝基还原酶是活化剂。还提供了一种使用上述化合物在样品中鉴定硝基还原酶的方法，其中硝基还原酶是活化剂。