7β-hydroxycholesterol | 570-97-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 7β-hydroxycholesterol
• 英文别名: 5β-cholestanediol-(3β.5)；3β.5-Dihydroxy-10.13-dimethyl-17β-((R)-1.5-dimethyl-hexyl)-5β-gonan；(10R)-3c.5c-Dihydroxy-10r.13c-dimethyl-17c-((R)-1.5-dimethyl-hexyl)-(8cH.9tH.14tH)-hexadecahydro-1H-cyclopenta[a]phenanthren；5β-Cholestandiol-(3β.5)；coprostane-3β,5β-diol；Cholestane-3beta,5beta-diol；(3S,5S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthrene-3,5-diol
• CAS: 570-97-8
• 化学式: C₂₇H₄₈O₂
• 分子量: 404.677
• InChiKey: YGJKELZDRWFHOR-JLLCDCETSA-N

物化性质

• 熔点：
  148-149 °C(Solv: ethanol (64-17-5))
• 沸点：
  498.9±28.0 °C(Predicted)
• 密度：
  1.017±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7β-hydroxycholesterol 在 吡啶 、 氯化亚砜 作用下， 生成
  参考文献：
  名称：

  类固醇环亚硫酸盐。三，类固醇3,5-环亚硫酸盐的构象和构型方面。

  摘要：

  3β，5β-二羟基胆甾烷与亚硫酰氯的反应显示产生环亚硫酸酯，其包含具有S ＝ O氧轴向或赤道的舟状杂环，取决于形成方式。在吡啶中在低温下对二醇进行处理有利于赤道S ＝ O构象，而在氯仿溶液中较高的反应温度产生轴向和赤道差向异构体的混合物。在7α-溴-6-氧代3，5-亚硫酸盐的情况下，已经表明，在用酸处理后，S ＝ O赤道异构体可以转化为轴向异构体。

  DOI：

  10.1016/0039-128x(75)90004-5
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 lithium aluminium tetrahydride 、 乙醚 作用下， 生成 7β-hydroxycholesterol
  参考文献：
  名称：

  Method Comparisons for Particulate Nitrate, Elemental Carbon, and PM_2.5 Mass in Seven U.S. Cities

  摘要：

  Methods that measure PM2.5 mass, total particulate NO3-, and elemental carbon (EC) were evaluated in seven U.S. cities from 1997 to 1999. Sampling was performed in Bakersfield, CA; Boston, MA; Chicago, IL; Dallas, TX; Philadelphia, PA; Phoenix, AZ; and Riverside, CA. Evaluating and validating methods that measure the components of fine mass are important to the effort of establishing a speciation-monitoring network. The Harvard Impactor (HI), which measures fine particle mass, showed excellent agreement (r(2) = 0.99) With the PM,, Federal Reference Method (FRM) for 81 24-hr samples in Riverside and Bakersfield. The HI also showed good precision (4.8%) for 243 24-hr collocated samples over eight studies.The Aethalometer was employed in six of the sampling locations to measure black carbon (BC). These values were compared to EC as measured from a quartz filter using thermal analysis. For the six cities combined, the two methods were highly correlated (r(2) = 0.94; 187 24-hr samples); however, the BC values were approximately 24% less than the EC measurements consistently across all six cites. This compares well to results observed for EC/BC measurements observed in other semi-urban areas. Particulate NO3- was measured using the Harvard-EPA Annular Denuder System (HEADS). This was compared to the NO3- measured from the HI Teflon (DuPont) filter to assess NO3- artifacts. Significant NO3- losses (approximately 50% of total NO3-) were found in Riverside, Philadelphia, and Boston, while minimal artifacts were observed in the other sites. Two types of HEADS configurations were employed in five cities. One system used a Na2CO3-coated glass fiber filter, and the other type used a nylon filter to collect volatilized NO3- from the Teflon filter. The HEADS with the Na2CO3-coated filter consistently underestimated the total particulate NO3- by approximately 20% compared to the nylon HEADS.

  DOI：

  10.1080/10473289.2000.10464152

文献信息

• Meiosis regulating compounds
  申请人：——

  公开号：US20030032824A1

  公开（公告）日：2003-02-13

  Certain compounds, structurally related to natural compounds which can be extracted i.a. from bull testes and from human follicular fluid, can be used for regulating the meiosis in oocytes and in male germ cells. Some of these compounds are useful in the treatment of infertility, whereas other compounds are useful as contraceptives. These compounds have the structural formula 1 wherein the substituents are as defined in the specification.

  某些化合物与天然化合物结构相关，可以从公牛睾丸和人类卵泡液中提取，用于调节卵母细胞和雄性生殖细胞的减数分裂。其中一些化合物在不孕症治疗中很有用，而其他化合物则可用作避孕药。这些化合物具有结构式1，其中取代基如规范中所定义。
• Is Emotional Intelligence an Advantage? An Exploration of the Impact of Emotional and General Intelligence on Individual Performance
  作者：Laura Thi Lam、Susan L. Kirby

  DOI：10.1080/00224540209603891

  日期：2002.2

  Emotional intelligence is an increasingly popular consulting tool. According to popular opinion and work-place testimonials, emotional intelligence increases performance and productivity; however, there has been a general lack of independent, systematic analysis substantiating that claim. The authors investigated whether emotional intelligence would account for increases in individual cognitive-based performance over and above the level attributable to traditional general intelligence. The authors measured emotional intelligence with the Multifactor Emotional Intelligence Scale (MEIS; J. D. Mayer, P. Salovey, & D. R. Caruso, 1997). As measured by the MEIS, overall emotional intelligence is a composite of the 3 distinct emotional reasoning abilities: perceiving, understanding, and regulating emotions (J. D. Mayer & P. Salovey, 1997). Although further psychometric analysis of the MEIS is warranted, the authors found that overall emotional intelligence, emotional perception, and emotional regulation uniquely explained individual cognitive-based performance over and beyond the level attributable to general intelligence.
• Development and Preliminary Evaluation of a Particulate Matter Emission Factor Model for European Motor Vehicles
  作者：Rakesh B. Singh、Jeremy J. Colls

  DOI：10.1080/10473289.2000.10464208

  日期：2000.10

  Although modeling of gaseous emissions from motor vehicles is now quite advanced, prediction of particulate emissions is still at an unsophisticated stage. Emission factors for gasoline vehicles are not reliably available, since gasoline vehicles are not included in the European Union (EU) emission test procedure. Regarding diesel vehicles, emission factors are available for different driving cycles but give little information about change of emissions with speed or engine load. We have developed size-specific speed-dependent emission factors for gasoline and diesel vehicles. Other vehicle-generated emission factors are also considered and the empirical equation for re-entrained road dust is modified to include humidity effects. A methodology is proposed to calculate modal (accelerating, cruising, or idling) emission factors. The emission factors cover particle size ranges up to 10 mum, either from published data or from user-defined size distributions.A particulate matter emission factor model (PMFAC), which incorporates virtually all the available information on particulate emissions for European motor vehicles, has been developed. PMFAC calculates the emission factors for five particle size ranges [i.e., total suspended particulates (TSP), PM10, PM5, PM2.5, and PM1] from both vehicle exhaust and nonexhaust emissions, such as tire wear, brake wear, and re-entrained road dust. The model can be used for an unlimited number of roads and lanes, and to calculate emission factors near an intersection in user-defined elements of the lane. PMFAC can be used for a variety of fleet structures. Hot emission factors at the user-defined speed can be calculated for individual vehicles, along with relative cold-to-hot emission factors. The model accounts for the proportions of distance driven with cold engines as a function of ambient temperature and road type (i.e., urban, rural, or motorway).A preliminary evaluation of PMFAC with an available dispersion model to predict the airborne concentration in the urban environment is presented. The trial was on the A6 trunk road where it passes through Loughborough, a medium-size town in the English East Midlands. This evaluation for TSP and PM(10)was carried out for a range of traffic fleet compositions, speeds, and meteorological conditions. Given the limited basis of the evaluation, encouraging agreement was shown between predicted and measured concentrations.
• Method Comparisons for Particulate Nitrate, Elemental Carbon, and PM_2.5 Mass in Seven U.S. Cities
  作者：Peter Babich、Mark Davey、George Allen、Petros Koutrakis

  DOI：10.1080/10473289.2000.10464152

  日期：2000.7

  Methods that measure PM2.5 mass, total particulate NO3-, and elemental carbon (EC) were evaluated in seven U.S. cities from 1997 to 1999. Sampling was performed in Bakersfield, CA; Boston, MA; Chicago, IL; Dallas, TX; Philadelphia, PA; Phoenix, AZ; and Riverside, CA. Evaluating and validating methods that measure the components of fine mass are important to the effort of establishing a speciation-monitoring network. The Harvard Impactor (HI), which measures fine particle mass, showed excellent agreement (r(2) = 0.99) With the PM,, Federal Reference Method (FRM) for 81 24-hr samples in Riverside and Bakersfield. The HI also showed good precision (4.8%) for 243 24-hr collocated samples over eight studies.The Aethalometer was employed in six of the sampling locations to measure black carbon (BC). These values were compared to EC as measured from a quartz filter using thermal analysis. For the six cities combined, the two methods were highly correlated (r(2) = 0.94; 187 24-hr samples); however, the BC values were approximately 24% less than the EC measurements consistently across all six cites. This compares well to results observed for EC/BC measurements observed in other semi-urban areas. Particulate NO3- was measured using the Harvard-EPA Annular Denuder System (HEADS). This was compared to the NO3- measured from the HI Teflon (DuPont) filter to assess NO3- artifacts. Significant NO3- losses (approximately 50% of total NO3-) were found in Riverside, Philadelphia, and Boston, while minimal artifacts were observed in the other sites. Two types of HEADS configurations were employed in five cities. One system used a Na2CO3-coated glass fiber filter, and the other type used a nylon filter to collect volatilized NO3- from the Teflon filter. The HEADS with the Na2CO3-coated filter consistently underestimated the total particulate NO3- by approximately 20% compared to the nylon HEADS.
• Steroid cyclicsulfites. III. Conformational and configurational aspects of steroid 3,5-cyclicsulfites
  作者：Dennis M. Bleile、Cecil E. Malmberg、Alex T. Rowland

  DOI：10.1016/0039-128x(75)90004-5

  日期：1975.7

  The reaction of 3beta, 5beta-dihydroxy cholestanes with thionyl chloride is shown to yield cyclicsulfite esters containing boat heterocyclic rings with the S=O oxygen axial or equatorial, depending upon the mode of formation. Treatment of a diol in pyridine at low temperature favors an equatorial S=O conformation while higher reaction temperatures in chloroform solution yield a mixture of axial and

  3β，5β-二羟基胆甾烷与亚硫酰氯的反应显示产生环亚硫酸酯，其包含具有S ＝ O氧轴向或赤道的舟状杂环，取决于形成方式。在吡啶中在低温下对二醇进行处理有利于赤道S ＝ O构象，而在氯仿溶液中较高的反应温度产生轴向和赤道差向异构体的混合物。在7α-溴-6-氧代3，5-亚硫酸盐的情况下，已经表明，在用酸处理后，S ＝ O赤道异构体可以转化为轴向异构体。