(2R)-3-(octadecanoyloxy)-2-(tetradecanoyloxy)propoxy(2-(trimethylammonio)ethoxy)phosphinic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: (2R)-3-(octadecanoyloxy)-2-(tetradecanoyloxy)propoxy(2-(trimethylammonio)ethoxy)phosphinic acid
• 英文别名: 2-[hydroxy-[(2R)-3-octadecanoyloxy-2-tetradecanoyloxypropoxy]phosphoryl]oxyethyl-trimethylazanium
• 化学式: C40H81NO8P+
• 分子量: 735.0
• InChiKey: MZWGYEJOZNRLQE-KXQOOQHDSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  13.5
• 重原子数：
  50
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• POLYNUCLEOTIDES ENCODING METHYLMALONYL-CoA MUTASE
  申请人：ModernaTX, Inc.

  公开号：US20200078314A1

  公开（公告）日：2020-03-12

  The disclosure relates to polynucleotides comprising an open reading frame of linked nucleosides encoding human methylmalonyl-CoA mutase precursor, human methylmalonyl-CoA mutase (MCM) mature form, or functional fragments thereof. In some embodiments, the disclosure includes methods of treating methylmalonic acidemia in a subject in need thereof comprising administering an mRNA encoding an MCM polypeptide.
• COMBINATIONS OF MRNAS ENCODING IMMUNE MODULATING POLYPEPTIDES AND USES THEREOF
  申请人：ModernaTX, Inc.

  公开号：US20200113844A1

  公开（公告）日：2020-04-16

  The disclosure relates to compositions and methods for the preparation, manufacture and therapeutic use of combinations of immunomodulatory polynucleotides (e.g., mRNAs) encoding an immune response primer polypeptide (e.g., an interleukin 23 (IL-23) polypeptide or an interleukin 36γ (IL-36-gamma) polypeptide), and an immune response co-stimulatory signal polypeptide (e.g., an OX40L polypeptide).
• STABILIZED FILTRATION DEVICE
  申请人：Aquammodate AB

  公开号：US20220152559A1

  公开（公告）日：2022-05-19

  A macromolecule membrane structure ( 2 ) comprises a membrane ( 3 ) with water-channeling integral membrane proteins (IMPS) ( 1 ) and is coated, on a first surface, with a silica layer ( 4 ). The silica layer ( 4 ) stabilizes the macromolecule membrane structure ( 2 ) and the water-channeling IMPS ( 1 ) while maintaining the water-channeling function of the water-channeling IMPs ( 1 ). As a consequence of this stabilization, the macromolecule membrane structure ( 2 ) may be used in a filtration device ( 5 ) for various filtration operations, including water purification.