1,4-Bis(3'-(trifluoromethyl)-6'-pyridyl)piperazine | 131136-84-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 1,4-Bis(3'-(trifluoromethyl)-6'-pyridyl)piperazine
• 英文别名: 1,4-Bis(5-(trifluoromethyl)-2-pyridyl)piperazine；1,4-bis[5-(trifluoromethyl)pyridin-2-yl]piperazine
• CAS: 131136-84-0
• 化学式: C₁₆H₁₄F₆N₄
• 分子量: 376.304
• InChiKey: NWJPVXBIUDRQLH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  32.3
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  哌嗪 、 2-氯-5-三氟甲基吡啶 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 100.0 ℃ 、800.0 MPa 条件下， 反应 72.0h， 以72%的产率得到1,4-Bis(3'-(trifluoromethyl)-6'-pyridyl)piperazine
  参考文献：
  名称：

  High-pressure functionalization of diaza-crown ethers: new synthesis of silver(1+) ion-specific binders

  摘要：

  High-pressure S(N)Ar reaction was first applied to the synthesis of a new crown ether family, which incorporated various heteroaromatics as potential cation binding sites in a unique fashion. In a CH2Cl2 liquid membrane transport experiment, several diaza-crown ethers having thiazole, oxazole, pyrazine, and pyridazine rings exhibited a perfect Ag+ ion selectivity. Cation extraction and C-13 NMR titration experiments revealed that attachment of a unique heterocycle to the diaza-crown ring, if in the proper position, significantly offered excellent Ag+ ion specificity. Since the binding and transport selectivities of these crown ethers were apparently higher than those with conventional crown ethers, the high-pressure technique provided a useful method for synthesis of a new specific crown ether family.

  DOI：

  10.1021/jo00028a027

文献信息

• MATSUMOTO, KIYOSHI;HASHIMOTO, SHIRO;MINATOGAWA, HIROYUKI;MUNAKATA, MEGUMU+, CHEM. EXPRESS., 5,(1990) N, C. 473-476
  作者：MATSUMOTO, KIYOSHI、HASHIMOTO, SHIRO、MINATOGAWA, HIROYUKI、MUNAKATA, MEGUMU+

  DOI：——

  日期：——
• High-pressure functionalization of diaza-crown ethers: new synthesis of silver(1+) ion-specific binders
  作者：Hiroshi Tsukube、Hiroyuki Minatogawa、Megumi Munakata、Mitsuo Toda、Kiyoshi Matsumoto

  DOI：10.1021/jo00028a027

  日期：1992.1

  High-pressure S(N)Ar reaction was first applied to the synthesis of a new crown ether family, which incorporated various heteroaromatics as potential cation binding sites in a unique fashion. In a CH2Cl2 liquid membrane transport experiment, several diaza-crown ethers having thiazole, oxazole, pyrazine, and pyridazine rings exhibited a perfect Ag+ ion selectivity. Cation extraction and C-13 NMR titration experiments revealed that attachment of a unique heterocycle to the diaza-crown ring, if in the proper position, significantly offered excellent Ag+ ion specificity. Since the binding and transport selectivities of these crown ethers were apparently higher than those with conventional crown ethers, the high-pressure technique provided a useful method for synthesis of a new specific crown ether family.