2,7-bis(morpholinosulfonyl)-9H-fluoren-9-one oxime

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,7-bis(morpholinosulfonyl)-9H-fluoren-9-one oxime
• 英文别名: N-[2,7-bis(morpholin-4-ylsulfonyl)fluoren-9-ylidene]hydroxylamine
• 化学式: C₂₁H₂₃N₃O₇S₂
• 分子量: 493.562
• InChiKey: YBRWACARTLGCDI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  33
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  143
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• [EN] SMALL MOLECULE FERROPTOSIS INDUCERS<br/>[FR] INDUCTEURS DE FERROPTOSE À PETITES MOLÉCULES
  申请人：UNIV COLUMBIA

  公开号：WO2018118711A1

  公开（公告）日：2018-06-28

  The present invention provides, inter alia, a compound according to formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.

  本发明提供了一种符合公式（I）的化合物，此外还提供了含有药学上可接受载体和本发明中化合物的组合物。进一步提供了在细胞中调节GPX4的方法以及在细胞中诱导铁死亡的方法。
• Small molecule ferroptosis inducers
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US10947188B2

  公开（公告）日：2021-03-16

  The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.

  本发明特别提供了一种符合式 (I) 的化合物： 还提供了含有药学上可接受的载体和根据本发明的化合物的组合物。此外，还提供了调节细胞中 GPX4 的方法和诱导细胞中铁细胞凋亡的方法。
• SMALL MOLECULE FERROPTOSIS INDUCERS
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US20190315681A1

  公开（公告）日：2019-10-17

  The present invention provides, inter alia, a compound according to formula (I): Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for regulating GPX4 in a cell and methods for inducing ferroptosis in a cell.