7-Hexyl-3-methyl-8-(2-oxo-propylsulfanyl)-3,7-dihydro-purine-2,6-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 7-Hexyl-3-methyl-8-(2-oxo-propylsulfanyl)-3,7-dihydro-purine-2,6-dione
• 英文别名: 7-hexyl-3-methyl-8-(2-oxopropylsulfanyl)purine-2,6-dione
• 化学式: C₁₅H₂₂N₄O₃S
• 分子量: 338.4
• InChiKey: VAXQRQMFCSGJEH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Selective Inhibitors Of i-NOS For Use Against Viral Infection
  申请人：UCL Business PLC

  公开号：US20180214430A1

  公开（公告）日：2018-08-02

  The present invention concerns compounds for use in the prevention of viral replication and/or the prevention or treatment of a viral infection, wherein the compounds are selective inhibitors of inducible nitric oxide synthase, and methods of preventing viral replication and/or preventing or treating viral infections in a subject comprising administering a prophylactically or therapeutically effective amount of the compounds.
• [EN] NOVEL 2-OXO-1,2,3,4-TETRAHYDROPYRIMIDINES, BICYCLIC PYRIMIDINE DIONES AND IMIDAZOLIDINE-2,4-DIONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS<br/>[FR] NOUVELLES 2-OXO-1,2,3,4-TÉTRAHYDROPYRIMIDINES, PYRIMIDINE DIONES BICYCLIQUES ET IMIDAZOLIDINE-2,4-DIONES UTILES COMME INHIBITEURS DE L'OXYDE NITRIQUE SYNTHASE INDUCTIBLE
  申请人：KALYPSYS INC

  公开号：WO2007101213A2

  公开（公告）日：2007-09-07

  [EN] The present invention relates to novel 2-oxo-l,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidizolidine-2,4-diones and methods useful as inhibitors of nitric oxide synthase.
  [FR] La présente invention concerne de nouvelles 2-oxo-1,2,3,4-tétrahydropyrimidines, pyrimidine diones bicycliques et imidizolidine-2,4-diones et des procédés, utiles comme inhibiteurs de l'oxyde nitrique synthase.