Theophyllin-(7)-essigsaeure- | 107152-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: Theophyllin-(7)-essigsaeure-
• 英文别名: N-(3-diethylamino-propyl)-2-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydro-purin-7-yl)-acetamide；N-[3-(diethylamino)propyl]-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide
• CAS: 107152-00-1
• 化学式: C₁₆H₂₆N₆O₃
• mdl: MFCD02106793
• 分子量: 350.421
• InChiKey: UNPJCEJITCNLSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  90.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] METHODS AND COMPOUNDS FOR TREATING ALCOHOL USE DISORDERS AND ASSOCIATED DISEASES<br/>[FR] PROCÉDÉS ET COMPOSÉS POUR LE TRAITEMENT DE TROUBLES D'UTILISATION D'ALCOOL ET DE MALADIES ASSOCIÉES
  申请人：PHARMATROPHIX INC

  公开号：WO2018039641A1

  公开（公告）日：2018-03-01

  Methods and compounds for treating alcohol use disorder and associated diseases. Included is the administering to a subject in need there of an effective amount of a compound having a modulating effect on p75NTR.

  治疗酒精使用障碍和相关疾病的方法和化合物。包括向需要的受试者施用对p75NTR具有调节作用的化合物的有效量。
• NEUROTROPHIN MIMETICS AND USES THEREOF
  申请人：Longo Frank M.

  公开号：US20110230479A1

  公开（公告）日：2011-09-22

  The present application is related to compounds which are novel neurotrophin mimetics. The application also discloses the treatment of disorders associated with p75 expression, such as degradation or dysfunction of cells expressing p75 in a mammal by administering an effective amount of such compounds.

  本申请涉及一种新型神经营养因子类似物化合物。该申请还公开了通过给哺乳动物施用有效量的这种化合物来治疗与p75表达相关的疾病，例如p75表达细胞的降解或功能障碍。
• Methods of facilitating cell survival using neurotrophin mimetics
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP2586445A1

  公开（公告）日：2013-05-01

  Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75NTR receptor molecule. Enhanced survival of neural and other cells has been observed.

  治疗神经退行性疾病和其他疾病的方法和化合物。其中包括向有需要的受试者施用有效量的对 p75NTR 受体分子具有结合特异性的化合物。已观察到神经细胞和其他细胞的存活率提高。
• METHODS OF FACILITATING CELL SURVIVAL USING NEUROTROPHIN MIMETICS
  申请人：UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL

  公开号：EP2594318B1

  公开（公告）日：2020-06-10
• PHARMACEUTICAL FORMULATIONS COMPRISING NEUROTROPHIN MIMETICS
  申请人：Longo Frank M.

  公开号：US20100267727A1

  公开（公告）日：2010-10-21

  Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75 NTR receptor molecule. Enhanced survival of neural and other cells has been observed.