p-[5-(1-imidazolyl)pentyloxy]phenol | 87477-63-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: p-[5-(1-imidazolyl)pentyloxy]phenol
• 英文别名: 4-{[5-(1H-Imidazol-1-yl)pentyl]oxy}phenol；4-(5-imidazol-1-ylpentoxy)phenol
• CAS: 87477-63-2
• 化学式: C₁₄H₁₈N₂O₂
• 分子量: 246.309
• InChiKey: WHVXEERBJDLCFA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  47.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-溴-2,2-二甲基己酸乙酯 、 p-[5-(1-imidazolyl)pentyloxy]phenol 生成 6-(4-(5-(1-咪唑基)戊氧基)苯氧基)-2,2-二甲基己酸乙酯
  参考文献：
  名称：

  Imidazolyl phenoxy compounds and method of use

  摘要：

  提供了咪唑基苯氧衍生物及含有这种衍生物的制药组合物。这些组合物对于降低受试者的脂质活性非常有用，因此对于降低胆固醇和甘油三酯非常有用。

  公开号：

  US04794113A1
• 作为产物：
  描述：

  1-{5-[4-(Benzyloxy)phenoxy]pentyl}-1H-imidazole 生成 p-[5-(1-imidazolyl)pentyloxy]phenol
  参考文献：
  名称：

  MATSUMOTO, ATSUSI;KODZIMA, ATSUO;OXATA, ISAO;SATO, NOBORU

  摘要：

  DOI：

文献信息

• Phenoxy imidazole compound
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04891432A1

  公开（公告）日：1990-01-02

  Novel phenoxy derivatives are provided which can be represented by the general formula: ##STR1## wherein the various substituents are as defined, and include compounds such as benzyl 6-[p-[5-(1-imidazolyl)pentyloxy]phenoxy]-2,2-dimethylhexanoate. The invention also encompasses pharmaceutical compositions containing the derivatives and their use in treating tumors.

  提供了一种新的苯氧衍生物，可以用一般公式表示：##STR1## 其中各种取代基的定义如上所述，包括如苯甲酸苄酯6-[p-[5-(1-咪唑基)戊氧基]苯氧基]-2,2-二甲基己酸酯等化合物。该发明还涵盖了含有这些衍生物的药物组合物及其在治疗肿瘤方面的应用。
• Certain thiazol-4-yl-phenoxy derivatives having lipid lowering properties
  申请人：——

  公开号：US04942242A1

  公开（公告）日：1990-07-17

  Thiazolyl phenoxy derivatives are provided as well as pharmaceutical compositions containing such derivatives. The compositions are useful for lowering lipid activity in a subject and accordingly useful for reducing cholesterol and triglycerides.

  提供了噻唑基苯氧衍生物，以及含有这些衍生物的药物组合物。这些组合物对于降低受试者的脂质活性非常有用，因此有助于降低胆固醇和甘油三酯。
• 6-[p-[5-(1-imidazolyl)pentyloxy]phenoxy]-2,2-dimethyl-hexanoic acid
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04987147A1

  公开（公告）日：1991-01-22

  Novel phenoxy derivatives are provided such as 6-[p-5-(1-imidazolyl)pentyloxy]phenoxy]-2,2-dimethyl-hexanoic acid, pharmaceutical compositions containing the derivative and their use in treating tumors.

  提供了新型的苯氧衍生物，如6-[p-5-(1-咪唑基)戊氧基]苯氧]-2,2-二甲基己酸，其中含有该衍生物的药物组合物及其在治疗肿瘤中的用途。
• Certain pyridyl or imidazol-1-yl-alkyleneoxy-(or
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04795753A1

  公开（公告）日：1989-01-03

  The present invention relates to novel phenoxy derivatives represented by the formula (I): ##STR1## wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group, B is group represented by the formula: --(CH.sub.2).sub.n --O--, --(CH.sub.2).sub.n CONH(CH.sub.2).sub.k -- or --(CH.sub.2).sub.n-N (R.sup.4)-- wherein k is 0 or an integer of 1 to 5, n is an integer of 1 to 6 and R.sup.4 is hydrogen or a lower alkyl group; m is 0 or an integer of 1 to 6; R.sup.1 is a hydroxyl group, an amino group or a lower alkoxy group; R.sup.2 and R.sup.3 which may be the same or different represent, a hydrogen atom or a lower alkyl group hereafter the same, having lipid lowering activity, and salts thereof.

  本发明涉及由公式（I）表示的新的苯氧衍生物：##STR1## 其中：A是咪唑基，吡啶基，吡啶氧基，B是由公式表示的基团：--（CH.sub.2）.sub.n--O--，--（CH.sub.2）.sub.nCONH（CH.sub.2）.sub.k--或--（CH.sub.2）.sub.n-N（R.sup.4）--，其中k为0或1至5的整数，n为1至6的整数，R.sup.4为氢或较低的烷基；m为0或1至6的整数；R.sup.1为羟基，氨基或较低的烷氧基；R.sup.2和R.sup.3可以相同也可以不同，表示氢原子或较低的烷基，具有降脂作用，以及其盐。
• Certain pyridinyl or imidazolinyl-4-thiazolyl-phenoxy alkanoic acid
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04798838A1

  公开（公告）日：1989-01-17

  The present invention relates to novel phenoxy derivatives represented by the formula (I): ##STR1## wherein: A is an imidazolyl group, a pyridyl group, a pyridyloxy group, an oxo-substituted chromenyloxy group, a lower alkyl group, an amino group which may be substituted with a phenyl group or a lower alkyl group, or a carbamoyl group substituted with a cyclohexylamino group or an imidazolylalkyl group; B is a single bond, a thiazolyl group which may be substituted with a lower alkyl group, a group represented by the formula: --(CH.sub.2).sub.n --O--, --(CH.sub.2).sub.n CONH(CH.sub.2).sub.k -- or --(CH.sub.2).sub.n --N(R.sup.4)-- wherein k is 0 or an integer of 1 to 5, n is an integer of 1 to 6 and R.sup.4 is hydrogen or a lower alkyl group; m is 0 or an integer of 1 to 6; R.sup.1 is a hydroxyl group, an amino group or a lower alkoxy group; R.sup.2 and R.sup.3 which may be the same or different, represent a hydrogen atom or a lower alkyl group hereafter the same: and salts thereof. In the definition of the groups appearing in the formulae in the specification, the term "lower" refers to a straight or branched carbon chain having 1 to 5 carbon atoms, preferably 1 to 3 carbon atoms. Accordingly, specific examples of lower alkyl groups include a methyl group, an ethyl group, a propyl group, an isopropyl group, a butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a pentyl (or amyl) group, an isopentyl group, a neopentyl group, a tert-pentyl group, etc.

  本发明涉及由式（I）表示的新型苯氧衍生物：##STR1## 其中：A是咪唑基团，吡啶基团，吡啶氧基团，氧代取代的香豆素氧基团，低碳基，氨基，该氨基可以被苯基或低碳基取代，或者是用环己氨基基团或咪唑基烷基基团取代的氨甲酰基基团；B是单键，可以被低碳基取代的噻唑基团，或由式表示的基团：--(CH.sub.2).sub.n --O--，--(CH.sub.2).sub.n CONH(CH.sub.2).sub.k --或--(CH.sub.2).sub.n --N(R.sup.4)--，其中k为0或1至5的整数，n为1至6的整数，R.sup.4为氢或低碳基；m为0或1至6的整数；R.sup.1为羟基，氨基或低烷氧基；R.sup.2和R.sup.3可以相同也可以不同，在此后均表示氢原子或低碳基；以及其盐。在规范中出现的基团的定义中，“低”一词是指具有1至5个碳原子的直链或支链碳链，最好是1至3个碳原子。因此，低碳基的具体例子包括甲基基团，乙基基团，丙基基团，异丙基基团，丁基基团，异丁基基团，仲丁基基团，叔丁基基团，戊基（或戊基）基团，异戊基基团，新戊基基团，叔戊基基团等。