1,2-dihydroacenaphthylen-4-ol | 6296-98-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,2-dihydroacenaphthylen-4-ol
• 英文别名: 4-Acenaphthenol
• CAS: 6296-98-6
• 化学式: C₁₂H₁₀O
• 分子量: 170.211
• InChiKey: OSSBHMYNGLXRNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1,2-dihydroacenaphthylen-4-ol 在 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 氯苯 为溶剂， 反应 5.0h， 生成 acenaphthylen-4-yl acetate
  参考文献：
  名称：

  Brown, Roger F. C.; Coulston, Karen J.; Eastwood, Frank W., Australian Journal of Chemistry, 1987, vol. 40, # 1, p. 107 - 120

  摘要：

  DOI：
• 作为产物：
  描述：

  4-aminoacenaphthene 在 硫酸 作用下， 生成 1,2-dihydroacenaphthylen-4-ol
  参考文献：
  名称：

  DE549058

  摘要：

  公开号：

文献信息

• [EN] PYRAZOLE-CONTAINING MACROPHAGE MIGRATION INHIBITORY FACTOR INHIBITORS<br/>[FR] INHIBITEURS DU FACTEUR INHIBITEUR DE MIGRATION DES MACROPHAGES CONTENANT DU PYRAZOLE
  申请人：UNIV YALE

  公开号：WO2019178480A1

  公开（公告）日：2019-09-19

  In one aspect, the invention comprises compounds that bind and inhibit macrophage migration inhibitory factor. In another aspect, the invention provides methods of treating inflammatory disease, neurological disorders and cancer using the compounds of the invention.

  在一个方面，该发明涉及结合并抑制巨噬细胞迁移抑制因子的化合物。在另一个方面，该发明提供使用该发明的化合物治疗炎症性疾病、神经系统疾病和癌症的方法。
• Optimization of Pyrazoles as Phenol Surrogates to Yield Potent Inhibitors of Macrophage Migration Inhibitory Factor
  作者：Vinay Trivedi‐Parmar、Michael J. Robertson、José A. Cisneros、Stefan G. Krimmer、William L. Jorgensen

  DOI：10.1002/cmdc.201800158

  日期：2018.6.6

  Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that is implicated in the regulation of inflammation, cell proliferation, and neurological disorders. MIF is also an enzyme that functions as a keto–enol tautomerase. Most potent MIF tautomerase inhibitors incorporate a phenol, which hydrogen bonds to Asn97 in the active site. Starting from a 113‐μm docking hit, we report results

  巨噬细胞迁移抑制因子（MIF）是促炎细胞因子，与炎症，细胞增殖和神经系统疾病的调节有关。MIF也是一种酶，起酮-烯醇互变异构酶的作用。大多数有效的MIF互变异构酶抑制剂都含有苯酚，该苯酚在活性位点与Asn97氢键结合。从113-μ起始米对接命中，我们报告，已经提供了取代的吡唑为具有60-70Ñ效力苯酚替代基于结构的和计算机辅助设计的结果米。MIF与吡唑配合物的晶体结构突出了与Lys32和Asn97的氢键作用，以及与Tyr36，Tyr95和Phe113的芳基-芳基相互作用对结合的贡献。
• POLYMERIZABLE MONOMER, POLYMER COMPOUND FOR CONDUCTIVE POLYMER, AND METHOD FOR PRODUCING THE POLYMER COMPOUND
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20200247926A1

  公开（公告）日：2020-08-06

  Polymerization reaction is performed using a polymerizable monomer shown by the following general formula (1) and at least one monomer selected from monomers each having a structure of a salt among a lithium salt, a sodium salt, a potassium salt, and a nitrogen compound salt of a fluorosulfonic acid or the like; then, the structure of the salt of the repeating unit of a polymer obtained by the polymerization reaction is changed to the fluorosulfonic acid or the like by ion exchange. Thus, the present invention provides a polymer compound for a conductive polymer and a method for producing the polymer compound which is suitably used as a dopant for a fuel cell and a conductive material, and which is a copolymer containing a repeating unit of styrene having a 3,3,3-trifluoro-2-hydroxy-2-trifluoromethylisobutyl ether group, and a repeating unit having any of a fluorosulfonic acid, a fluorosulfonimide group, and a n-carbonyl-fluoro-sulfonamide group.

  聚合反应使用以下一般式（1）所示的可聚合单体和至少一种选择自锂盐、钠盐、钾盐和氟磺酸盐等盐结构的单体中的单体进行；然后，通过离子交换将聚合反应得到的聚合物的重复单元的盐结构改变为氟磺酸盐或类似物。因此，本发明提供了一种用作导电聚合物的聚合物化合物以及用作燃料电池和导电材料的掺杂剂的聚合物化合物的生产方法，该聚合物是含有3,3,3-三氟-2-羟基-2-三氟甲基异丁基醚基的苯乙烯重复单元和具有氟磺酸、氟磺酰亚胺基团和n-羰基-氟磺酰胺基团中的任何一种的重复单元的共聚物。
• CONDUCTIVE POLYMER COMPOSITION, COATED ARTICLE, AND PATTERNING PROCESS
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：EP3153553A1

  公开（公告）日：2017-04-12

  The present invention provides a conductive polymer composition including: (A) a n-conjugated conductive polymer having at least one repeating unit shown by the following general formulae (1-1), (1-2), and (1-3); (B) a dopant polymer which contains a repeating unit "a" shown by the following general formula (2) and has a weight-average molecular weight in a range of 1,000 to 500,000; and (C) an amphoteric ion compound shown by the following general formula (3). This provides a conductive polymer composition having good filterability, good coating property and film-formability onto a substrate to form a conductive film with good film quality, and good peelability with H2O or an alkaline developer; and forming a conductive film which reveals antistatic performance with high charge discharging ability and does not affect an influence of acid on the adjoined layer to be contact with; thereby being suitably usable for a antistatic film in resist lithography using electron beam and so on, as well as a transparent electrode, a carrier implanted layer, and a carrier transferring layer of an organic thin-film device.

  本发明提供了一种导电聚合物组合物，其中包括：(A)具有至少一个重复单元的 n-共轭导电聚合物，如下文通式(1-1)、(1-2)和(1-3)所示；(B)掺杂聚合物，该聚合物含有如下文通式(2)所示的重复单元 "a"，其重量平均分子量在 1,000 至 500,000 之间；以及(C)两性离子化合物，如下文通式(3)所示。这就提供了一种导电聚合物组合物，它具有良好的过滤性、良好的涂覆性和在基材上成膜性，可形成具有良好成膜质量的导电膜，并且在使用 H2O 或碱性显影剂时具有良好的可剥离性；并形成具有高电荷放电能力的抗静电性能的导电膜，且不会影响酸对与之接触的毗邻层的影响；从而可适用于使用电子束等进行抗蚀光刻的抗静电膜，以及有机薄膜器件的透明电极、载体植入层和载体转移层。
• Conductive polymer composite and substrate
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US10020089B2

  公开（公告）日：2018-07-10

  The present invention provides a conductive polymer composite including (A) a π-conjugated polymer and (B) a dopant polymer which contains a repeating unit “a” represented by the following general formula (1) and has a weight-average molecular weight in the range of 1,000 to 500,000, wherein R1 represents a hydrogen atom or a methyl group; R2 represents a fluorine atom or a trifluoromethyl group; Z represents a single bond or —C(═O)—O—; “m” is an integer of 1 to 4; and “a” is a number satisfying 0

  本发明提供了一种导电聚合物复合材料，包括(A)π-共轭聚合物和(B)掺杂聚合物，其中掺杂聚合物含有由以下通式(1)表示的重复单元 "a"，其重量平均分子量在 1,000 至 500,000 之间、 其中 R1 代表氢原子或甲基；R2 代表氟原子或三氟甲基；Z 代表单键或-C(═O)-O-；"m "是 1 至 4 的整数；"a "是满足 0＜a≤1.0 的数字。本发明可提供一种导电聚合物复合材料，该复合材料通过旋涂具有优异的过滤性和成膜性，并且在由该复合材料形成薄膜时，可形成具有高透明度和平整度的导电薄膜。