4-(3-tert-butyldimethylsilanyloxypropyl)-3-thiosemicarbazide | 741723-11-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-(3-tert-butyldimethylsilanyloxypropyl)-3-thiosemicarbazide
• 英文别名: 4-(3-t-Butyldimethylsilanyloxypropyl)-3-thiosemicarbazide；1-amino-3-[3-[tert-butyl(dimethyl)silyl]oxypropyl]thiourea
• CAS: 741723-11-5
• 化学式: C₁₀H₂₅N₃OSSi
• 分子量: 263.48
• InChiKey: DEBZXQGWKZPCDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.74
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  91.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(3-tert-butyldimethylsilanyloxypropyl)-3-thiosemicarbazide 、 N-[3-(6(R,S)-bromo-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-2-yl)-2-oxo-oxazolidin-5 (S)-ylmethyl]-acetamide 以gave the title compound in 20% yield (0.086 g)的产率得到(S)-N-{3-[3-(3-hydroxy-propylamino)-1,4,5,6-tetrahydro-1,2-diaza-benzo[e]azulen-8-yl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
  参考文献：
  名称：

  Antibacterial agents

  摘要：

  本文披露了I式化合物及其制备方法。此外，还披露了制备具有生物活性的I式化合物的方法，以及包含I式化合物的药学上可接受的组合物的方法。本文所披露的I式化合物可以用于多种应用，包括用作抗菌剂。

  公开号：

  US20050288273A1
• 作为产物：
  描述：

  3-(叔丁基二甲基甲硅烷基氧基)丙胺 在 一水合肼 、 三乙胺 作用下， 以 甲醇 、 乙醚 、 乙二醇甲醚 为溶剂， 生成 4-(3-tert-butyldimethylsilanyloxypropyl)-3-thiosemicarbazide
  参考文献：
  名称：

  Synthesis and SAR of novel conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system

  摘要：

  A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. Certain aniino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.(c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.05.085

文献信息

• Antibacterial agents
  申请人：Boyer Earl Frederick

  公开号：US20050288273A1

  公开（公告）日：2005-12-29

  Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.

  本文披露了I式化合物及其制备方法。此外，还披露了制备具有生物活性的I式化合物的方法，以及包含I式化合物的药学上可接受的组合物的方法。本文所披露的I式化合物可以用于多种应用，包括用作抗菌剂。
• Synthesis and SAR of novel conformationally restricted oxazolidinones possessing Gram-positive and fastidious Gram-negative antibacterial activity. Part 2: Amino substitutions on heterocyclic D-ring system
  作者：Allison L. Choy、J.V.N. Vara Prasad、Frederick E. Boyer、Michael D. Huband、Michael R. Dermyer

  DOI：10.1016/j.bmcl.2007.05.085

  日期：2007.8

  A novel series of conformationally restricted oxazolidinones was synthesized, in which the heterocyclic D ring was substituted with various amino groups. Several analogs exhibited potent activity against both Gram-positive and fastidious Gram-negative organisms. Certain aniino-substituted analogs also exhibited improved aqueous solubility compared to the corresponding un-substituted heterocyclic D-ring analogs.(c) 2007 Elsevier Ltd. All rights reserved.