Dimethyl-(2-{3-[1-pyridin-2-yl-meth-(E)-ylidene]-3H-inden-1-yl}-ethyl)-amine | 351422-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚和异茚
• 英文名称: Dimethyl-(2-{3-[1-pyridin-2-yl-meth-(E)-ylidene]-3H-inden-1-yl}-ethyl)-amine
• 英文别名: (1E)-N,N-Dimethyl-1-(2-pyridinylmethylene)-1H-indene-3-ethanamine；N,N-dimethyl-2-[(3E)-3-(pyridin-2-ylmethylidene)inden-1-yl]ethanamine
• CAS: 351422-78-1
• 化学式: C₁₉H₂₀N₂
• 分子量: 276.381
• InChiKey: GVOLYPPAXQIHQQ-JQIJEIRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  茚 在 氢氧化钾 、 正丁基锂 作用下， 以 甲醇 、 乙醚 为溶剂， 生成 Dimethyl-(2-{3-[1-pyridin-2-yl-meth-(E)-ylidene]-3H-inden-1-yl}-ethyl)-amine
  参考文献：
  名称：

  Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands

  摘要：

  In our search for M-2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M-2-subtype selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00186-x

文献信息

• Design and pharmacology of quinuclidine derivatives as M2-selective muscarinic receptor ligands
  作者：Thomas M Böhme、Christine Keim、Gerd Dannhardt、Ernst Mutschler、Günter Lambrecht

  DOI：10.1016/s0960-894x(01)00186-x

  日期：2001.5

  In our search for M-2-selective muscarinic receptor antagonists, we synthesized 1,3-disubstituted indenes. The effects of different basic moieties with regard to binding and selectivity towards the five distinct muscarinic receptor subtypes were investigated. The results show that the quinuclidine series afforded the most promising compounds in terms of both receptor affinity and M-2-subtype selectivity. (C) 2001 Elsevier Science Ltd. All rights reserved.