ethyl (1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetimidate | 1242146-38-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl (1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetimidate
• 英文别名: ethyl (1E)-N-(4-oxo-2-phenylquinazolin-3-yl)ethanimidate
• CAS: 1242146-38-8
• 化学式: C₁₈H₁₇N₃O₂
• 分子量: 307.352
• InChiKey: XJHJLXNFBSJCTQ-DEDYPNTBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  54.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl (1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetimidate 、 对氨基苯酚 在 溶剂黄146 、 盐酸 作用下， 以 甲醇 为溶剂， 以77%的产率得到N'-(4-oxo-2-phenyl-3(4H)-quinazolinyl)-N-(4-hydroxyphenyl)acetamidine hydrochloride
  参考文献：
  名称：

  A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines

  摘要：

  A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures' determination of the synthesized compounds was carried out using spectroscopic techniques including IR, (1)H NMR, and mass spectrometry. Structural effects on reactivity were also studied. (C) 2010 Rasool Khan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.04.009
• 作为产物：
  描述：

  3-氨基-2-苯基-4(3H)-喹唑啉酮 、 原乙酸三乙酯 在 溶剂黄146 作用下， 反应 5.0h， 以83%的产率得到ethyl (1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetimidate
  参考文献：
  名称：

  A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines

  摘要：

  A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures' determination of the synthesized compounds was carried out using spectroscopic techniques including IR, (1)H NMR, and mass spectrometry. Structural effects on reactivity were also studied. (C) 2010 Rasool Khan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

  DOI：

  10.1016/j.cclet.2010.04.009

文献信息

• A facile synthesis of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines
  作者：Rasool Khan、Mohammad Arfan、Javeed Mahmood、Shazia Anjum、M. Iqbal Choudhary

  DOI：10.1016/j.cclet.2010.04.009

  日期：2010.8

  A series of novel unsymmetrical N-(4-oxo-2-phenyl-3(4H)-quinazolinoyl)-N-(aryl)acetamidines was synthesized by reacting ethyl(1E)-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)ethanimidoate (2) and suitable reactive aromatic amines. Structures' determination of the synthesized compounds was carried out using spectroscopic techniques including IR, (1)H NMR, and mass spectrometry. Structural effects on reactivity were also studied. (C) 2010 Rasool Khan. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.