4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-3,9-dicarboxylic acid | 130733-62-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 菲咯啉
• 英文名称: 4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-3,9-dicarboxylic acid
• 英文别名: 4,10-Dioxo-1,4,7,10-tetrahydro-[1,7]phenanthrolin-3,9-dicarbonsaeure；4,10-Dihydroxy-1,7-phenanthroline-3,9-dicarboxylic acid；4,10-dioxo-1,7-dihydro-1,7-phenanthroline-3,9-dicarboxylic acid
• CAS: 130733-62-9
• 化学式: C₁₄H₈N₂O₆
• 分子量: 300.227
• InChiKey: GIFCDUXKRJFRTJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  133
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-3,9-dicarboxylic acid 在 五氯化磷 、 mineral oil 、 三氯氧磷 作用下， 生成 4,10-dichloro-m-phenanthroline
  参考文献：
  名称：

  The Synthesis of Some 4,10-Disubstituted-1,7-phenanthroline Derivatives

  摘要：

  DOI：

  10.1021/ja01633a053
• 作为产物：
  描述：

  4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-3,9-dicarboxylic acid diethyl ester 在 氢氧化钾 作用下， 生成 4,10-dioxo-1,4,7,10-tetrahydro-[1,7]phenanthroline-3,9-dicarboxylic acid
  参考文献：
  名称：

  The Synthesis of Some 4,10-Disubstituted-1,7-phenanthroline Derivatives

  摘要：

  DOI：

  10.1021/ja01633a053

文献信息

• Assays for identification of topoisomerase inhibitors
  申请人：Stivers T. James

  公开号：US20080020973A1

  公开（公告）日：2008-01-24

  The instant invention provides a continuous spectroscopic assay for DNA topoisomerase activity. The invention further provides topoisomerase inhibitors and pharmaceutical compositions for the treatment of topoisomerase associated diseases and disorders.
• METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS
  申请人：Reed John C.

  公开号：US20090118135A1

  公开（公告）日：2009-05-07

  An assay for determining compounds that inhibit activity of a BCl-2 protein, or affect conversion of Bcl-2 from an antiapoptotic to a proapoptotic form are described. In addition, compounds that modulate the function of anti-apoptotic proteins such as Bcl-2 and related Bcl-2 family members are identified.
• TGF-BETA MODULATORS AND METHODS FOR USING THE SAME
  申请人：Burmester James K.

  公开号：US20090176870A1

  公开（公告）日：2009-07-09

  The present invention provides a method of modulating TGF-β activity in a subject. Methods of the present invention comprise administering to the subject an effective amount of a compound of the formula: or a salt, prodrug, tautomer, hydrate, solvate, or stereoisomer thereof, wherein a is an integer from 0 to 4; each R 1 is independently hydroxy, alkoxy, halide, alkyl, cyano, nitro, amino, monoalkylamino, dialkylamino, or carboxy; R 2 is aryl, cycloalkyl, alkenyl, or alkyl, each of which is optionally substituted; each of X 1 and X 2 is independently O, S or NR 3 , wherein R 3 is hydrogen or alkyl; X 3 is hydrogen, alkoxy, alkyl, hydroxy, halide, amino, monoalkylamino, or dialkylamino; and X 4 is alkoxy, hydroxy, halide, amino, monoalkylamino, or dialkylamino.
• The Synthesis of Some 4,10-Disubstituted-1,7-phenanthroline Derivatives
  作者：Alexander R. Surrey、Royal A. Cutler

  DOI：10.1021/ja01633a053

  日期：1954.2