1,3-dioxane-5,5-dimethanamine | 104275-08-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二恶烷
• 英文名称: 1,3-dioxane-5,5-dimethanamine
• 英文别名: 5,5-Bis-(aminomethyl)-1,3-dioxane；[5-(aminomethyl)-1,3-dioxan-5-yl]methanamine
• CAS: 104275-08-3
• 化学式: C₆H₁₄N₂O₂
• mdl: MFCD19205608
• 分子量: 146.189
• InChiKey: PVGDTRYBROZOIA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  70.5
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-dioxane-5,5-dimethanamine 、 dipotassium;platinum(2+);tetrachloride 、 水 以81%的产率得到
  参考文献：
  名称：

  BITHA, PANAYOTA;CARVAJAL, SUZANNE G.;CITARELLA, RONALD V.;SANTOS, EUGENIA+, J. MED. CHEM., 32,(1989) N, C. 2063-2067

  摘要：

  DOI：
• 作为产物：
  描述：

  5,5-bis(bromomethyl)-1,3-dioxane 在 Lindlar's catalyst sodium azide 、 氢气 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 生成 1,3-dioxane-5,5-dimethanamine
  参考文献：
  名称：

  A new family of water-soluble, third-generation antitumor platinum complexes

  摘要：

  [1,1-Cyclobutanedicarboxylato(2)-O,O'](1,3-dioxane-5,5-dimethan amine- N,N')platinum(II), 3a, a third generation, very water-soluble platinum complex, has been synthesized along with several of its analogues. All members of the new family contain a 1,3-dioxane or 1,3-dioxolane-1,3-diamine as their basic ligand, a moiety which contributes to their increased water solubility, and a bidentate acid ligand, which is responsible for their good stability. They were all easily crystallized and characterized by 1H NMR and elemental analysis, and the parent complex 3a was further characterized by 13C NMR. Their very desirable physical properties combined with their broad spectrum of antitumor activity and reduced toxicity make them good candidates of further development.

  DOI：

  10.1021/jm00129a008

文献信息

• WATER SOLUBLE PLATINUM COMPLEXES FOR TUMOR TREATMENT AND PROCESS OF PREPARING SAME
  申请人：GUDUI BIOPHARMA TECHNOLOGY INC.

  公开号：US20150051387A1

  公开（公告）日：2015-02-19

  Disclosed are water-soluble platinum complexes for tumor treatment and preparation method, said platinum complexes being shown as formula (I); The present platinum complexes exhibiting superior cytotoxicity and efficacy compare to the clinical drug oxaliplatin, the design strategy of the present platinum complexes is to enhance the solubility and stability favor its clinical use.

  本文披露了一种用于肿瘤治疗的水溶性铂配合物及其制备方法，所述铂配合物表示为式（I）；本文的铂配合物在细胞毒性和疗效方面优于临床药物奥沙利铂，本文的铂配合物设计策略是增强其溶解性和稳定性，有利于其临床应用。
• FLUORINE-CONTAINING WATER SOLUBLE PLATINUM COMPLEXES FOR TUMOR TREATMENT AND PROCESS OF PREPARING SAME
  申请人：Wang Yiqiang

  公开号：US20150011740A1

  公开（公告）日：2015-01-08

  Disclosed are fluorine-containing highly water-soluble platinum complexes for tumor treatment and preparation method, said platinum complexes being shown as formula (I); The present fluorine-containing platinum complexes exhibiting superior cytotoxicity and efficacy compare to the clinical drug oxaliplatin, the design strategy of the present platinum complexes is to enhance the solubility and stability favor its clinical use.

  本发明公开了一种用于肿瘤治疗的含氟高水溶性铂配合物及其制备方法，该铂配合物的化学式为(I)。本发明的含氟铂配合物与临床药物奥沙利铂相比，表现出更优异的细胞毒性和疗效。本发明的设计策略是增强铂配合物的溶解度和稳定性，以便其在临床上使用。
• Synthesis of cisplatin analogs
  申请人：American Cyanamid Company

  公开号：US04808730A1

  公开（公告）日：1989-02-28

  This disclosure sets forth a novel process for producing cisplatin analogs which possess antitumor activity.

  这份披露说明了一种生产具有抗肿瘤活性的顺式铂类似物的新方法。
• Water soluble platinum complexes of novel malonate derivatives
  申请人：American Cyanamid Company

  公开号：US04870070A1

  公开（公告）日：1989-09-26

  This disclosure describes water soluble platinum complexes of novel malonate derivatives which possess the property of inhibiting the growth of tumors in mammals.

  本披露描述了一种新型丙二酸衍生物的水溶性铂配合物，具有抑制哺乳动物肿瘤生长的特性。
• Synthesis of cisplatinum analogs
  申请人：AMERICAN CYANAMID COMPANY

  公开号：EP0296321B1

  公开（公告）日：1992-09-23