(2R,4R,5S)-2-[(3S,4R,6R)-6-[(3S,4R,6R)-6-[(3S,4R,6S)-6-azido-2-ethyl-4,5-dimethyloxan-3-yl]oxy-2-ethyl-4,5-dimethyloxan-3-yl]oxy-2-ethyl-4,5-dimethyloxan-3-yl]oxy-6-ethyl-5-[(2R,4R,5S)-6-ethyl-5-[(2R,4S,5S)-6-ethyl-3,4,5-trimethyloxan-2-yl]oxy-3,4-dimethyloxan-2-yl]oxy-3,4-dimethyloxane

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧烷类
• 英文名称: (2R,4R,5S)-2-[(3S,4R,6R)-6-[(3S,4R,6R)-6-[(3S,4R,6S)-6-azido-2-ethyl-4,5-dimethyloxan-3-yl]oxy-2-ethyl-4,5-dimethyloxan-3-yl]oxy-2-ethyl-4,5-dimethyloxan-3-yl]oxy-6-ethyl-5-[(2R,4R,5S)-6-ethyl-5-[(2R,4S,5S)-6-ethyl-3,4,5-trimethyloxan-2-yl]oxy-3,4-dimethyloxan-2-yl]oxy-3,4-dimethyloxane
• 化学式: C55H99N3O11
• 分子量: 978.4
• InChiKey: SAWBCLLFOVEUHK-OZNNMDGSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.5
• 重原子数：
  69
• 可旋转键数：
  17
• 环数：
  6.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  116
• 氢给体数：
  0
• 氢受体数：
  13

文献信息

• Sulfated oligosaccharide derivatives
  申请人：Ferro Vito

  公开号：US20070185037A1

  公开（公告）日：2007-08-09

  The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds; compositions comprising the compounds, and use of the compounds and compositions thereof for the antiangiogenic, antimetastatic, anti-inflammatory, antimicrobial, anticoagulant and/or antithrombotic treatment, lowering of blood triglyceride levels and inhibition of cardiovascular disease of a mammalian subject.

  该发明涉及一种多硫酸寡糖衍生物化合物，其具有作为肝素硫酸结合蛋白抑制剂和肝素酶抑制剂的活性；制备该化合物的方法；包含该化合物的组合物；以及使用该化合物和其组合物进行抗血管生成、抗转移、抗炎、抗微生物、抗凝血和/或抗血栓治疗、降低哺乳动物受试者的血甘油三酯水平和抑制心血管疾病的方法。
• US7875592B2
  申请人：——

  公开号：US7875592B2

  公开（公告）日：2011-01-25