Acetic acid [5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyltetrahydrofuran-3-yl] ester

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: Acetic acid [5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-hydroxymethyltetrahydrofuran-3-yl] ester
• 英文别名: [5-(4-benzamido-2-oxopyrimidin-1-yl)-2-(hydroxymethyl)oxolan-3-yl] acetate
• 化学式: C₁₈H₁₉N₃O₆
• 分子量: 373.4
• InChiKey: YHQCWFGKRPKMDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  118
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Thermally-cleavable protecting and linker groups
  申请人：EVONETIX LTD

  公开号：US11161869B2

  公开（公告）日：2021-11-02

  The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.

  本发明涉及化学连接体和保护基团、含有化学连接体或保护基团的化合物和组合物，以及可用于制备它们的中间体和工艺。这些化学连接剂和保护基团以吡咯烷和哌啶活化基团为基础，在加热并释放二氧化碳时，这些基团会发生分子内旋转，从而将有机化合物从底物中释放出来。这些化学连接剂和保护基团尤其适用于根据以下代表性方案进行寡核苷酸的固相合成。
• THERMALLY-CLEAVABLE PROTECTING AND LINKER GROUPS
  申请人：EVONETIX LTD

  公开号：US20210107934A1

  公开（公告）日：2021-04-15

  The present invention relates to chemical linkers and protecting groups, compounds and compositions containing the chemical linkers or protecting groups, and intermediates and processes that can be used to prepare them. The chemical linkers and protecting groups are based on pyrrolidine and piperidine activating groups, which undergo intramolecular cyclisation upon heating with release of carbon dioxide, thereby releasing the organic compound from a substrate. In particular, those chemical linkers and protecting groups are useful in the solid phase synthesis of oligonucleotides according to the following representative schemes.