2-amino-9-(2-hydroxyethoxymethyl)-2,3-dihydro-1H-purin-6-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 2-amino-9-(2-hydroxyethoxymethyl)-2,3-dihydro-1H-purin-6-one
• 化学式: C₈H₁₃N₅O₃
• 分子量: 227.22
• InChiKey: XFKAHIMCPPCZLL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  114
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHODS FOR TREATING FLAVIVIRUSES AND ZIKA INFECTIONS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US20210052621A1

  公开（公告）日：2021-02-25

  There are provided, inter alia, methods of treatment of Zika virus infection.
• [EN] METHODS FOR TREATING FLAVIVIRUSES AND ZIKA INFECTIONS<br/>[FR] MÉTHODES DE TRAITEMENT DES FLAVIVIRUS ET DES INFECTIONS PAR LE VIRUS ZIKA
  申请人：UNIV CALIFORNIA

  公开号：WO2018136559A1

  公开（公告）日：2018-07-26

  Provided are methods of treatment of Zika virus infection. Specifically, the disclosure provides methods of treating a Zika viral infection in a subject in need thereof, said methods comprising administering to said subject an effective amount of a therapeutic composition including an NS5 (non-structural (NS) protein 5) polymerase inhibitor. Further disclosed are NS5 inhibitors that can be used for the methods.