3-Diallylamino-propanol-1 | 17719-78-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-Diallylamino-propanol-1
• 英文别名: 3-[Di(prop-2-en-1-yl)amino]propan-1-ol；3-[bis(prop-2-enyl)amino]propan-1-ol
• CAS: 17719-78-7
• 化学式: C₉H₁₇NO
• mdl: MFCD15209039
• 分子量: 155.24
• InChiKey: NYYFUGDLDDZGTO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.555
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-Diallylamino-propanol-1 在 sodium hypochlorite 、 三苯基膦 、 cesium fluoride 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 甲苯 、 乙腈 为溶剂， 反应 5.5h， 生成 5-allyl-3,3a,4,5,6,7-hexahydroisoxazolo[4,3-c]pyridine
  参考文献：
  名称：

  分子内一氧化氮-烯烃环加成反应全合成（+）-艾比丁宁

  摘要：

  （+）-癫痫素的全合成以9个步骤完成，总产率为48％，其中将INOC用作构建喹喔啉骨架的关键步骤。我们发现通过常规方法制备关键中间体（R）-N-（3-硝基丙基）-2-乙烯基哌啶或（R）-（2-乙烯基哌啶-1-基）丙醛是极其困难的任务。因此，通过使用福山的肟合成法，开发了一种不使用相应的醛就能将3-（N，N-二烷基氨基）丙醇高效转化为3-（N，N-二烷基氨基）丙肟的通用方法。

  DOI：

  10.1021/jo101910r
• 作为产物：
  描述：

  3-(N,N-diallylamino)-propanal 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 0.33h， 以56%的产率得到3-Diallylamino-propanol-1
  参考文献：
  名称：

  Chesney, Antony; Marko, Istvan E., Synthetic Communications, 1990, vol. 20, # 20, p. 3167 - 3180

  摘要：

  DOI：

文献信息

• IONIC COMPOUNDS HAVING A SILYLOXY GROUP
  申请人：HYDRO-QUÉBEC

  公开号：US20150093655A1

  公开（公告）日：2015-04-02

  There is provided an ionic compound having attached thereto a silyloxy group. There is also provided methods of making this ionic compound as well as electrolytes, electrochemical cells and capacitors comprising this ionic compound.

  提供了一种具有硅氧基团的离子化合物。还提供了制备该离子化合物的方法，以及包含该离子化合物的电解质、电化学电池和电容器。
• METHOD FOR SYNTHESISING BIS[3-(N,N-DIALKYLAMINO)PROPYL]ETHERS
  申请人：IFP Energies nouvelles

  公开号：US20140336416A1

  公开（公告）日：2014-11-13

  The invention relates to an improved method for synthesizing bis[3-(N,N-dialkylamino)propyl]ethers from acrylonitrile, comprising the following reactions: first addition reaction of a water molecule and an acrylonitrile molecule to produce 3-hydroxypropionitrile (reaction 1), second addition reaction of a 3-hydroxypropionitrile molecule obtained by reaction 1 and an acrylonitrile molecule to produce bis(2-cyanoethyl)ether (reaction 2), hydrogenation reaction of the bis(2-cyanoethyl)ether to conduct a reduction of the nitrile functions to primary amine functions in order to produce bis(3-aminopropyl)ether (reaction 3), aminoalkylation reaction of the bis(3-aminopropyl)ether to produce bis[3-(N,N-dialkylamino)propyl]ether (reaction 4).

  该发明涉及一种改进的方法，用于从丙烯腈合成双[3-(N,N-二烷基氨基)丙基]醚，包括以下反应：第一步是水分子和丙烯腈分子的加成反应，产生3-羟基丙腈（反应1）；第二步是通过反应1得到的3-羟基丙腈分子和丙烯腈分子的加成反应，产生双(2-氰乙基)醚（反应2）；将双(2-氰乙基)醚氢化，将腈官能团还原为一次胺官能团，从而产生双(3-氨基丙基)醚（反应3）；将双(3-氨基丙基)醚进行氨基烷基化反应，产生双[3-(N,N-二烷基氨基)丙基]醚（反应4）。
• METHOD FOR PRODUCING POLYALKYLENE GLYCOL DERIVATIVE HAVING AMINO GROUP AT END
  申请人：Shin-Etsu Chemical Co., Ltd.

  公开号：US20160159831A1

  公开（公告）日：2016-06-09

  A method simply produces a narrowly distributed and high-purity polyalkylene glycol derivative having an amino group at an end without using a heavy metal catalyst. A method for producing a polyalkylene glycol derivative having an amino group at the end by reacting a compound represented by the general formula (V) with an alkylene oxide, then reacting a reaction product with an electrophile represented by the general formula (I), and deprotecting the obtained product without using a heavy metal: R A 3 O(R A 4 O) k-1 R A 4 O − M + (V) wherein R A 3 represents a linear; branched, or cyclic hydrocarbon group having 1 to 20 carbon atoms; R A 4 represents an alkylene group having 2 to 8 carbon atoms; k represents an integer of 2 to 5; and M represents an alkali metal; wherein R A 1a and R A 1b each independently represent a protective group of the amino group, or one of R A 1a and R A 1b represents H and the other represents a protective group of the amino group, or R A 1a and R A 1b bind to each other to form a cyclic protective group, and the protective group is deprotectable without using a heavy metal; R A 2 represents a linear, branched, or cyclic hydrocarbon group having 1 to 6 carbon atoms; and X represents a leaving group.

  一种方法通过将一个由一般式（V）表示的化合物与一种烷基氧化物反应，然后将反应产物与一个由一般式（I）表示的亲电试剂反应，并在不使用重金属的情况下去保护所得产物，从而简单地产生一个具有末端氨基的狭窄分布和高纯度的聚烷基二醇衍生物的方法：RA3O(RA4O)k-1RA4O−M+（V），其中RA3代表具有1到20个碳原子的线性、分支或环烃基；RA4代表具有2到8个碳原子的烷基基团；k代表2到5的整数；M代表碱金属；其中RA1a和RA1b分别独立地代表氨基的保护基，或者RA1a和RA1b中的一个代表H，另一个代表氨基的保护基，或者RA1a和RA1b结合在一起形成一个环状保护基，且该保护基可在不使用重金属的情况下去保护；RA2代表具有1到6个碳原子的线性、分支或环烃基；X代表一个离去基团。
• Pharmaceutically useful bis-basic ester and thioester derivatives
  申请人：Richardson-Merrell Inc.

  公开号：US03946112A1

  公开（公告）日：1976-03-23

  Bis-basic ester derivatives of the following general formula are useful in the treatment of conditions of delayed hypersensitivity. ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, or N-(lower)alkyl carbazole; X represents oxygen or sulfur; A represents a straight or branched alkylene chain of from 2 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 is hydrogen, straight or branched lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.

  以下通式的Bis-basic酯衍生物在治疗迟发性超敏症状方面很有用。其中[W]代表从芴、荧蒽、荧蒽-9-醇、荧蒽-9-酮、咔唑或N-(较低)烷基咔唑中选择的芳香多环核；X代表氧或硫；A代表2到6个碳原子的直链或支链烷基链；R1和R2中的每一个都是氢、1到4个碳原子的直链或支链低烷基，或3到6个碳原子的烯基，其中乙烯不饱和度不在1位；以及其药用酸盐。
• PROCESS FOR THE MANUFACTURE OF BENZYLSULFONYLARENES
  申请人：Levent Mahmut

  公开号：US20090012308A1

  公开（公告）日：2009-01-08

  The present invention provides a process for the manufacture of an arylmethyl-sulfonylarene, R 1 CH 2 SO 2 R 2 , wherein R 1 and R 2 are each independently an optionally substituted phenyl or naphthyl group which process comprises reacting an arylmethylhalide, R 1 CH 2 -Hal wherein R 1 is as defined hereinabove and Hal is Cl, Br or I with a sodium arylsulfinate R 2 SO 2 Na wherein R 2 is as defined hereinabove in the presence of a base optionally in the presence of a solvent. Also provided is the use of the inventive process in the manufacture of a 3-arylsulfonylindazole 5-HT6 ligand.

  本发明提供了一种制备芳基甲基磺酰基芳烃R1CH2SO2R2的方法，其中R1和R2各自独立地为可选择取代的苯基或萘基。该方法包括将芳基甲基卤化物R1CH2-Hal（其中R1如上所定义，Hal为Cl、Br或I）与钠芳基磺酸盐R2SO2Na（其中R2如上所定义）在碱的存在下反应，可选择在溶剂的存在下进行。本发明还提供了将该创新过程用于制备3-芳基磺酰基吲哚5-HT6配体的用途。