6-羟基-1H-萘嵌苯-1-酮 | 3352-82-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 非那烯类
• 中文名称: 6-羟基-1H-萘嵌苯-1-酮
• 英文名称: 6-Hydroxyphenalenone
• 英文别名: 6-hydroxy-perinaphthenone；6-hydroxy-phenalen-1-one；6-Hydroxy-phenalen-1-on；6-Hydroxy-perinaphthenon；6-Hydroxyperinaphthenon；6-Hydroxy-1H-phenalen-1-one；6-hydroxyphenalen-1-one
• CAS: 3352-82-7
• 化学式: C₁₃H₈O₂
• mdl: MFCD00453101
• 分子量: 196.205
• InChiKey: RTFXINFACWRPDI-UHFFFAOYSA-N

物化性质

• 熔点：
  295-297 °C (decomp)
• 沸点：
  424.6±45.0 °C(Predicted)
• 密度：
  1.392±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2914400090

反应信息

• 作为反应物：
  描述：

  6-羟基-1H-萘嵌苯-1-酮 在 ammonium hydroxide 作用下， 反应 4.0h， 以52%的产率得到6-氨基-1-萉酮
  参考文献：
  名称：

  Solodar', S. L.; Vinogradov, L. M., Journal of Organic Chemistry USSR (English Translation), 1980, p. 936 - 937

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲氧基-1-萘丙酸 在 PPA 作用下， 生成 6-羟基-1H-萘嵌苯-1-酮
  参考文献：
  名称：

  Cooke et al., Australian Journal of Chemistry, 1958, vol. 11, p. 230,233

  摘要：

  DOI：

文献信息

• Improved synthesis of natural isomeric naphthoxanthenones
  作者：Julian Barrera、Edwin Patiño、Felipe Otálvaro

  DOI：10.1016/j.tetlet.2019.151359

  日期：2020.1

  5-methoxy-1H-naphtho[2,1,8-mna]xanthen-1-one (1) and 5-methoxy-3H-naphtho[2,1,8-mna]xanthen-3-one (musafluorone 2), a pair of positional isomers isolated from Wachendorfia thyrsiflora and Musa acuminata, were synthesized in six steps in an overall yield of 53 % and 59 % starting from the corresponding methoxyphenalenones and employing an acid mediated cyclocondensation strategy. Preliminary assays

  5-甲氧基-1 H-萘[2,1,8 - mna ]黄原-1-酮（1）和5-甲氧基-3 H-萘[2,1,8 - mna ]黄原-3-酮（Musafluorne 2），从相应的甲氧基对苯二酚开始，采用酸介导的环缩合策略，分六步合成了一对从Wachendorfia thyrsiflora和Mus acuminata分离出的位置异构体，总收率分别为53％和59％。初步测定证明了化合物1和2嵌入DNA的能力。
• Synthesis of[phenyl-13C6]lachnanthocarpone and other13C-labelled phenylphenalenones
  作者：Felipe Otálvaro、Winston Quiñones、Fernando Echeverri、Bernd Schneider

  DOI：10.1002/jlcr.808

  日期：2004.2

  [phenyl-13C6]Lachnanthocarpone ([phenyl-13C6]2,6-dihydroxy-9-phenylphenalen-1-one), a hypothetical intermediate in the biosynthesis of various natural phenylphenalenones, was prepared in four steps using [U-13C]bromobenzene to introduce the label. Based on related methodologies further native phenylphenalenones such as [phenyl-13C6]anigorufone, [1-13C]anigorufone and [4′-O13CH3]4′-methoxyanigorufone were synthesized in labelled form. Copyright © 2004 John Wiley & Sons, Ltd.

  [苯基-13C6]Lachnanthocarpone（[苯基-13C6]2,6-二羟基-9-苯基苯丙烯-1-酮）是多种天然苯丙烯酮生物合成过程中的假定中间体，利用[U-13C]溴苯引入标记，分四个步骤制备了该中间体。在相关方法的基础上，进一步合成了[苯基-13C6]苯并吡喃酮、[1-13C]苯并吡喃酮和[4′-O13CH3]4′-甲氧基苯并吡喃酮等标记形式的原生苯并芘。Copyright © 2004 John Wiley & Sons, Ltd. All Rights Reserved.
• Phenalenimine fluorescent dyes and their use in analytical compositions, elements and methods
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0353868A3

  公开（公告）日：1990-12-05

  Certain phenalenimine fluorescent compounds are useful in biomedical and analytical determinations. These compounds can be used for staining cells, as well as for the determination of various analytes found in human or animal biological fluids. Such determinations can be carried out in solution or by using dry analytical elements. The fluorescent compounds can be reacted with quinone nuclei to form reducible compounds which are also useful in analytical methods. In addition, the compounds can be incorporated into what are known as "loadable" latex particles to form detectable labels and biological reagents.

  某些苯并咪唑荧光化合物在生物医学和分析测定中非常有用。这些化合物可用于染色细胞，以及用于确定人或动物生物液体中发现的各种分析物。这种测定可以在溶液中进行，也可以使用干燥的分析元素进行。荧光化合物可以与醌核反应形成可还原化合物，这些化合物在分析方法中也很有用。此外，这些化合物可以被纳入所谓的“可装载”乳胶颗粒中，形成可检测的标签和生物试剂。
• Hydrolyzable fluorescent substrates and analytical determinations using same
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0231125A2

  公开（公告）日：1987-08-05

  Hydrolyzable substrates comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum absorptions above 530 nm and maximum emissions at 580 nm or above at physiological pH. These substrates can be used in analytical determinations of hydrolytic substances including hydrolytic enzymes or biological cells containing such enzymes.

  可水解底物包括被阻断的染料分子，这些分子在水解过程中从底物上裂解时，可产生荧光染料，在生理 pH 值下，最大吸收波长在 530 nm 以上，最大发射波长在 580 nm 以上。这些底物可用于分析测定水解物质，包括水解酶或含有此类酶的生物细胞。
• Hydrolyzable fluorescent substrates for phosphatases and analytical use thereof
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0232129A2

  公开（公告）日：1987-08-12

  Hydrolyzable substrates for acid and alkaline phosphatases comprise blocked dye moieties which, when cleaved from the substrate during hydrolysis, provide fluorescent dyes having maximum absorptions above 530 nm and maximum fluorescent emissions at least 580 nm. The dyes are blocked prior to hydrolysis with a phosphono or thioxophosphono group or a salt thereof. These substrates can be used in analytical determinations of acid or alkaline phosphatase, or in competitive binding reactions to determine immunologically reactive substances.

  酸性和碱性磷酸酶的可水解底物包括被封端的染料分子，当水解过程中染料分子从底物上裂解时，可产生最大吸收波长高于 530 nm、最大荧光发射波长至少为 580 nm 的荧光染料。 这些染料在水解前被膦酰基或硫代膦酰基或其盐封端。 这些底物可用于酸性或碱性磷酸酶的分析测定，或用于竞争性结合反应以测定免疫反应性物质。